Lamin-B in systemic inflammation, tissue homeostasis, and aging
Lamin-B in systemic inflammation, tissue homeostasis, and aging
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DOI：
10.1080/19491034.2015.1040212
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发表时间：
2015-05-01
期刊：
影响因子：
3.7
通讯作者：
Zheng, Yixian
中科院分区：
文献类型：
--
作者：
Chen, Haiyang;Zheng, Xiaobin;Zheng, Yixian
组织功能的逐渐丧失（或体内平衡）是衰老的自然过程，被认为会导致许多与年龄相关的疾病。在人类流行病学研究中，老年人的低度慢性全身性炎症与衰老相关病理的发展有关。尽管人们怀疑组织衰退与全身性炎症有关，但人们对这些衰老现象的原因和后果知之甚少。通过对果蝇脂肪体和肠道的研究，我们发现了一种机制，通过这种机制，随着年龄的增长，脂肪体中的层粘连蛋白b的减少会引起与年龄相关的全身炎症。这种慢性炎症导致肠道局部免疫反应受到抑制，进而导致肠道干细胞过度增殖和错分化，从而导致肠道增生。在这里，我们根据已发表的研究结果和新的观察结果讨论其影响和遗留问题。
Gradual loss of tissue function (or homeostasis) is a natural process of aging and is believed to cause many age-associated diseases. In human epidemiology studies, the low-grade and chronic systemic inflammation in elderly has been correlated with the development of aging related pathologies. Although it is suspected that tissue decline is related to systemic inflammation, the cause and consequence of these aging phenomena are poorly understood. By studying the Drosophila fat body and gut, we have uncovered a mechanism by which lamin-B loss in the fat body upon aging induces age-associated systemic inflammation. This chronic inflammation results in the repression of gut local immune response, which in turn leads to the over-proliferation and mis-differentiation of the intestinal stem cells, thereby resulting in gut hyperplasia. Here we discuss the implications and remaining questions in light of our published findings and new observations.