Self-administration of orally-delivered phencyclidine and ethanol under concurrent fixed-ratio schedules in rhesus monkeys.
Self-administration of orally-delivered phencyclidine and ethanol under concurrent fixed-ratio schedules in rhesus monkeys.
复制标题
在恒河猴中按照同时固定比例的方案自行口服苯环己哌啶和乙醇。
DOI：
10.1007/bf02439578
复制
发表时间：
1987
影响因子：
3.4
通讯作者：
Carroll,ME
中科院分区：
文献类型：
--
作者：
Carroll,ME
对5只猴子进行训练，在持续3h的并行固定比例16(FR 16)程序下，给5只猴子口服苯环利定(0.25 mg/ml)和水，用8%(w/v)的乙醇溶液代替水，然后提供以下一系列苯环利定浓度：0.25，0.5，1，0.03，0.06，0.12，0(水)和0.25 mg/ml(重测)。然后，苯环利定浓度保持恒定(0.25 mg/ml)，乙醇浓度变化如下：8、16、32、1、2、4、0(水)和8%w/v(重测)。每个药物浓度系列在同时提供水的情况下再次进行测试。在苯环利定浓度较低时，首选乙醇溶液，但在较高浓度苯环利定时，苯环利定的释放量高于乙醇释放量。低浓度苯环利定(0.03、0.06和0.12 mg/ml)对乙醇维持反应有促进作用，最高浓度(1 mg/ml)对乙醇维持反应有轻微抑制作用。除4%乙醇外，苯环利定优于所有浓度的乙醇。乙醇(8%)在较低浓度时抑制苯环利定维持行为，但在较高浓度时不起作用。苯环利定(0.25 mg/ml)或水同时存在时，乙醇浓度-反应函数几乎相同。药物偏好通常在疗程的前10分钟内就很明显，这表明它们是基于嗅觉、味道或其他直接的进食后效应。这些结果表明，在独立操作的FR方案下，两种口服给药可能同时自我给药。一种药物维持的行为取决于同时可用的替代强化药物的大小。
Five monkeys were trained to self-administer orally-delivered phencyclidine (0.25 mg/ml) and water under concurrent fixed-ratio 16 (FR 16) schedules during daily sessions that lasted 3 h. An 8% (w/v) ethanol solution was substituted for water and then the following series of phencyclidine concentrations was presented: 0.25, 0.5, 1, 0.03, 0.06, 0.12, 0 (water), and 0.25 mg/ml (retest). Next, the phencyclidine concentration was held constant (0.25 mg/ml), and the ethanol concentration was varied as follows: 8, 16, 32, 1, 2, 4, 0 (water), and 8% w/v (retest). Each drug concentration series was tested again with water concurrently available. At low phencyclidine concentrations the ethanol solution was preferred, but phencyclidine deliveries exceeded ethanol deliveries at higher phencyclidine concentrations. Ethanol-maintained responding was increased by the lower phencyclidine concentrations (0.03, 0.06 and 0.12 mg/ml), and it was slightly suppressed by the highest concentration (1 mg/ml). Phencyclidine was preferred to all concentrations of ethanol except 4%. Ethanol (8%) suppressed phencyclidine-maintained behavior at lower concentrations, but it had no effect at higher phencyclidine concentrations. The ethanol concentration-response functions were nearly identical whether phencyclidine (0.25 mg/ml) or water was concurrently present. Drug preferences were usually evident within the first 10 min of the session, suggesting they were based on olfaction, taste, or other immediate postingestional effects. These results show that two orally-delivered drugs may be concurrently self-administered under independently-operating FR schedules. Behavior maintained by one drug depends on the magnitude of the concurrently available, alternative reinforcing drug.