Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia
Spontaneous orofacial movements induced in rodents by very long-term neuroleptic drug administration: phenomenology, pathophysiology and putative relationship to tardive dyskinesia
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长期服用精神安定药物引起的啮齿动物自发口面部运动：现象学、病理生理学以及与迟发性运动障碍的假定关系
DOI：
10.1007/bf02244220
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发表时间：
2005
影响因子：
3.4
通讯作者：
J. Waddington
中科院分区：
文献类型：
--
作者：
J. Waddington
While understanding of the major clinical and ethical issue of tardive dyskinesia would be greatly facilitated by the development of an isomorphic or homologous animal model, particularly in rodents, this has proved to be a highly contentious issue. The literature on orofacial function in rats administered neuroleptic drugs for substantial proportions of their adult lifespan is reviewed. It reveals the emergence of late-onset orofacial movements in a number of studies, but very early-onset movements or no effect in others. Potential explantations for these discrepancies are considered, and ways of resolving such inconsistencies are suggested. The relationship of these various orofacial phenomena to dopaminergic and non-dopaminergic function, and to clinical syndromes, is critically evaluated.
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整合迟发性运动障碍的发病率和患病率。
影响因子：
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作者：
Kane,JM;Woerner,M;Borenstein,M;Wegner,J;Lieberman,J
通讯作者：
Lieberman,J
抗胆碱能挑战和精神安定药戒断。
影响因子：
--
作者：
Gardos,G;Cole,JO;Rapkin,RM;LaBrie,RA;Baquelod,E;Moore,P;Sovner,R;Doyle,J
通讯作者：
Doyle,J
影响因子：
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作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
通讯作者：
J. Kane;G. Honigfeld;J. Singer;H. Meltzer
迟发性运动障碍的患病率、严重程度和恢复情况随年龄的变化。
影响因子：
--
作者：
Smith,JM;Baldessarini,RJ
通讯作者：
Baldessarini,RJ
迟发性运动障碍的药理学特征。
影响因子：
2.9
作者：
Lieberman,J;Pollack,S;Lesser,M;Kane,J
通讯作者：
Kane,J