Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics.
Inhibition of polyphosphoinositide phosphodiesterase by aminoglycoside antibiotics.
复制标题
氨基糖苷类抗生素对多磷酸肌醇磷酸二酯酶的抑制作用。
DOI：
10.1007/bf00965878
复制
发表时间：
1985
影响因子：
4.4
通讯作者：
Agranoff,BW
中科院分区：
文献类型：
--
作者：
VanRooijen,LA;Agranoff,BW
The calcium-activated phosphodiesteratic hydrolysis of32P-labeled phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 4-phosphate in prelabeled nerve ending membranes is inhibited by the aminoglycosides neomycin and gentamicin, and to a lesser extent, by streptomycin. The inhibition is overcome by increasing concentrations of Ca2+, indicating that the aminoglycosides exert their effect by displacing Ca2+from lipid.
