Time-resolved optical imager for assessment of cerebral oxygenation
Time-resolved optical imager for assessment of cerebral oxygenation
复制标题
DOI：
10.1117/1.2743964
复制
发表时间：
2007-05-01
影响因子：
3.5
通讯作者：
Maniewski, Roman
中科院分区：
文献类型：
--
作者：
Kacprzak, Michal;Liebert, Adam;Maniewski, Roman
提出了一种时间分辨光学仪器，允许对脑氧合进行无创评估。该仪器配备了皮秒二极管激光器、快速光电探测器和时间相关的单光子计数电子设备。这项技术能够深度分辨估计吸收的变化，并因此评估大脑皮层中血红蛋白浓度的变化。氧合血红蛋白(HBO(2))和脱氧血红蛋白(Hb)的变化可以使用在近红外区的两个波长测量的光子飞行时间分布的矩来选择性地评估脑外和脑内组织间的变化。将从多个来源获得的数据和位于头部表面的探测器与基于矩的深度分辨分析相结合，可以对皮质氧合进行成像。给出了在运动刺激实验中对物理模型的测试结果以及仪器的体内验证。(C)2007年，光学仪器工程师学会。
A time-resolved optical instrument allowing for noninvasive assessment of cerebral oxygenation is presented. The instrument is equipped with picosecond diode lasers, fast photodetectors, and time-correlated single photon counting electronics. This technology enables depth-resolved estimation of changes in absorption and, in consequence, assessment of changes in hemoglobin concentrations in the brain cortex. Changes in oxyhemoglobin (HbO(2)) and deoxyhemoglobin (Hb) can be evaluated selectively in extra- and intracerebral tissue compartments using the moments of distributions of times of flight of photons measured at two wavelengths in the near-infrared region. The combination of the data acquired from multiple sources and detectors located on the surface of the head with the depth-resolved analysis, based on the moments, enables imaging of cortex oxygenation. Results of the tests on physical phantoms as well as in vivo validation of the instrument during the motor stimulation experiment are presented. (C) 2007 Society of Photo-Optical Instrumentation Engineers.