Betaxolol attenuates retinal ischemia/reperfusion damage in the rat
Betaxolol attenuates retinal ischemia/reperfusion damage in the rat
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DOI：
10.1097/00001756-200310270-00006
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发表时间：
2003-10-27
期刊：
影响因子：
1.7
通讯作者：
Choi, WS
中科院分区：
文献类型：
--
作者：
Cheon, EW;Park, CH;Choi, WS
本研究旨在阐明0.25%倍他洛尔对大鼠缺血再灌注损伤后神经元细胞损伤的保护作用。在再灌注开始后局部应用倍他洛尔，在再灌注后7天通过视网膜形态测定和胆碱乙酰转移酶免疫反应性评价其效果。在未治疗的眼中，再灌注期为3天和7天后，内丛状层厚度明显下降。然而，当眼睛缺血再灌注损伤后给予倍他洛尔治疗时，视网膜内丛状层厚度的减少和视网膜胆碱乙酰转移酶的免疫反应性均明显减弱。这些结果提示倍他洛尔是一种有效的神经保护剂，可预防大鼠视网膜缺血性损伤引起的细胞损伤。
This study was performed to elucidate the protection afforded by post-treatment with Betoptic (0.25% betaxolol) against neuronal cell damage after ischemia/reperfusion insult in rats. Betaxolol was applied topically after the start of reperfusion and its effect was evaluated by morphometry and choline acetyltransferase immunoreactivity of retinas at 7 days after reperfusion. In non-treated eyes, the thickness of the inner plexiform layer decreased markedly after a reperfusion period of both 3 and 7 days. However, when eyes were treated with betaxolol after ischemia/reperfusion injury, both the reduction of the inner plexiform layer thickness and the retinal choline acetyltransferase immunoreactivity were significantly attenuated. These findings suggest that betaxolol is an efficient neuroprotective agent and prevents the retinal cell damage induced by ischemic injury in rats.