Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography.
Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography.
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DOI：
10.1016/j.mibio.2003.09.009
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发表时间：
2003-11-01
影响因子：
3.1
通讯作者：
Huang, Yiyun
中科院分区：
文献类型：
--
作者：
Laruelle, Marc;Slifstein, Mark;Huang, Yiyun
在脑的分子成像中，许多因素影响可以从成像过程中导出的定量信息的可靠性。本文讨论了与放射性示踪剂本身有关的影响成像质量的因素。在受体定量的关键概念的简要总结，一些这些因素进行了讨论，包括选择性，亲和力，交付，和亲脂性。然后通过回顾最近开发的用于标记5-羟色胺转运蛋白的四种试剂（[（11）C]ADAM、[（11）C]DASB、[（11）C]达帕和[（11）C]AFM）的比较评价来说明理论部分中讨论的概念。具体而言，亲和力和亲脂性，在体外测量，和几个扫描参数之间的关系进行了研究。这些包括外周代谢、脑摄取、所需扫描时间、非特异性结合和结合潜力。结果表明，在一个给定的结构家族，亲和力和亲脂性与扫描结果在一个相对可预测的方式。
In molecular imaging of the brain, many factors affect the reliability of the quantitative information that can be derived from the imaging process. This article discusses factors impacting on the imaging quality that are related to the radiotracer per se. Following a brief summary of key concepts in receptor quantification, a number of these factors are discussed, including selectivity, affinity, delivery, and lipophilicity. Concepts discussed in the theoretical section are then illustrated, by reviewing a recent comparative evaluation of four agents developed to label the serotonin transporter ([(11)C]ADAM, [(11)C]DASB, [(11)C]DAPA, and [(11)C]AFM). Specifically, the relationship between affinity and lipophilicity, measured in vitro, and several scanning parameters are investigated. These include peripherical metabolism, brain uptake, required scanning time, nonspecific binding, and binding potential. It is shown that, within a given structural family, affinity and lipophilicity are associated with scan outcome in a relatively predictable manner.