Tissue proteomics in pancreatic cancer study: discovery, emerging technologies, and challenges.
Tissue proteomics in pancreatic cancer study: discovery, emerging technologies, and challenges.
复制标题
胰腺癌研究中的组织蛋白质组学：发现、新兴技术和挑战。
DOI：
10.1002/pmic.201200319
复制
发表时间：
2013
期刊：
影响因子：
3.4
通讯作者：
Chen,Ru
中科院分区：
文献类型：
--
作者：
Pan,Sheng;Brentnall,TeresaA;Kelly,Kimberly;Chen,Ru
胰腺癌是一种高致死率、难诊断、难治疗的疾病，近年来蛋白质组学技术特别是定量蛋白质组学的发展，引起了人们对胰腺癌研究的极大兴趣。多种组织蛋白质组学方法已被应用于胰腺癌及其相关疾病的研究。这些研究的目的各不相同，旨在更好地了解胰腺肿瘤发生的分子机制，改善治疗方法，并鉴定癌症相关蛋白质特征、信号传导事件以及癌细胞与肿瘤微环境之间的相互作用。本文就近年来胰腺癌组织蛋白质组学的研究进展作一综述。
Pancreatic cancer is a highly lethal disease that is difficult to diagnose and treat. The advances in proteomics technology, especially quantitative proteomics, have stimulated a great interest in applying this technology for pancreatic cancer study. A variety of tissue proteomics approaches have been applied to investigate pancreatic cancer and the associated diseases. These studies were carried out with various goals, aiming to better understand the molecular mechanisms underlying pancreatic tumorigenesis, to improve therapeutic treatment and to identify cancer associated protein signatures, signaling events as well as interactions between cancer cells and tumor microenvironment. Here, we provide an overview on the tissue proteomics studies of pancreatic cancer reported in the past few years in light of discovery and technology development.