The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study
The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study
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DOI：
10.1006/nimg.2002.1198
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发表时间：
2002-11-01
期刊：
影响因子：
5.7
通讯作者：
Kawashima, R
中科院分区：
文献类型：
--
作者：
Watanabe, J;Sugiura, M;Kawashima, R
前额皮质的重要作用之一是抑制运动。我们应用事件相关的功能磁共振成像 (fMRI) 技术来观察 GO/NO-GO 任务期间整个大脑 fMRI 信号的变化，以识别与 NO-GO 决策相关的激活功能场。 11 名正常受试者参与了这项研究，该研究由 30 项 GO 试验和 30 项 NO-GO 试验组成的随机系列组成。受试者被指示在 GO 信号出现后立即按下鼠标按钮。然而，当出现“禁止”信号时，他们被指示不要移动。我们检测到与准备阶段、GO 响应和 NO-GO 响应相关的 AM 信号的显着变化。与NO-GO反应相关的激活场位于双侧中额叶皮质、左侧背侧前运动区、左侧后顶内皮质和右侧枕颞区。与 GO 反应相关的激活区域存在于左侧初级感觉运动、右侧小脑前小叶、双侧丘脑以及从前扣带回到辅助运动区 (SMA) 的区域。与准备阶段相关的大脑激活在左侧背侧前运动区、左侧枕叶区、右侧腹侧前运动区、右侧梭形区以及从前扣带回到 SMA 的区域中被识别。结果表明，由双侧前额叶、顶内和枕颞叶皮质组成的大脑网络可能在执行“NO-GO”反应中发挥重要作用。 (C) 2002 年爱思唯尔科学（美国）。
One of the important roles of the prefrontal cortex is inhibition of movement. We applied an event-related functional magnetic resonance imaging (fMRI) technique to observe changes in fMRI signals of the entire brain during a GO/NO-GO task to identify the functional fields activated in relation to the NO-GO decision. Eleven normal subjects participated in the study, which consisted of a random series of 30 GO and 30 NO-GO trials. The subjects were instructed to press a mouse button immediately after the GO signal was presented. However, they were instructed not to move when the NO-GO signal was presented. We detected significant changes in AM signals in relation to the preparation phases, GO responses, and NO-GO responses. The activation fields related to the NO-GO responses were located in the bilateral middle frontal cortices, left dorsal premotor area, left posterior intraparietal cortices, and right occipitotemporal area. The fields of activation in relation to the GO responses were found in the left primary sensorimotor, right cerebellar anterior lobule, bilateral thalamus, and the area from the anterior cingulate to the supplementary motor area (SMA). Brain activations related to the preparation phases were identified in the left dorsal premotor, left lateral occipital, right ventral premotor, right fusiform, and the area from the anterior cingulate to the SMA. The results indicate that brain networks consisting of the bilateral prefrontal, intraparietal, and occipitotemporal cortices may play an important role in executing a NO-GO response. (C) 2002 Elsevier Science (USA).