Regenerative therapy for hypothyroidism: Mechanisms and possibilities.
Regenerative therapy for hypothyroidism: Mechanisms and possibilities.
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DOI：
10.1016/j.mce.2016.11.012
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发表时间：
2017-04-15
影响因子：
4.1
通讯作者：
Kotton DN
中科院分区：
文献类型：
--
作者：
Hollenberg AN;Choi J;Serra M;Kotton DN
从胚胎干细胞（ESC）或诱导多能干细胞（iPSC）中获取功能性甲状腺滤泡细胞的能力将为先天性或术后甲状腺功能减退症患者提供潜在的治疗益处。此外，了解甲状腺滤泡细胞发育的过程也将有助于深入了解调节源自内胚层的其他组织发育的关键步骤。在这里，我们回顾了对甲状腺滤泡细胞发育过程的理解进展，包括创建了两种模型，通过移植来自小鼠胚胎干细胞的甲状腺滤泡细胞来拯救甲状腺功能减退的小鼠受体。该领域的快速进展表明，在不久的将来，人类 ESC 或 iPSC 也应该能取得同样的成功。此外，ESC 或 iPSC 衍生的甲状腺滤泡细胞模型将为探索基因突变、药物或疾病如何以细胞自主方式影响甲状腺功能提供理想的系统。
The ability to derive functional thyroid follicular cells from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) would provide potential therapeutic benefit for patients with congenital or post-surgical hypothyroidism. Furthermore, understanding the process by which thyroid follicular cells develop will also provide great insight into the key steps that regulate the development of other tissues derived from endoderm. Here we review the advances in our understanding of the process of thyroid follicular cell development including the creation of two models that have allowed for the rescue of hypothyroid mouse recipients through the transplantation of thyroid follicular cells derived from mouse ESCs. Rapid progress in the field suggests that the same success should be achievable with human ESCs or iPSCs in the near future. Additionally, the availability of ESC or iPSC-derived thyroid follicular cell models will provide ideal systems to explore how genetic mutations, drugs or illness impact thyroid function in a cell-autonomous fashion.