Eu3+ functionalized Sc-MOFs: Turn-on fluorescent switch for ppb-level biomarker of plastic pollutant polystyrene in serum and urine and on-site detection by smartphone
Eu3+ functionalized Sc-MOFs: Turn-on fluorescent switch for ppb-level biomarker of plastic pollutant polystyrene in serum and urine and on-site detection by smartphone
复制标题
Eu3功能化Sc-MOF：打开血清和尿液中塑料污染物聚苯乙烯ppb级生物标志物的荧光开关并通过智能手机进行现场检测
DOI：
10.1016/j.bios.2017.06.018
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发表时间：
2017-11-15
影响因子：
12.6
通讯作者：
Yan, Bing
中科院分区：
文献类型：
--
作者：
Lian, Xiao;Miao, Tifang;Yan, Bing
塑料污染物对人类和环境的危害越来越受到人们的重视。聚苯乙烯(PS)和苯乙烯是生产玻璃纤维增强聚酯时大量使用的有毒化合物。本工作设计了一种简便的血清和尿液中聚苯乙烯和苯乙烯生物标志物(苯乙醇酸，PGA)的独立检测方法。我们制备了Eu3+功能化的Sc基金属有机骨架作为PGA的开启荧光开关。PGA的加入对Eu@MOF的发光有明显的增强作用。研制的荧光开关具有灵敏度高(LOD=4.16 ppb)、响应时间快(小于5 S)、线性范围宽(0.02~0.5 mg/mL)等特点。此外，Eu@MOFS表现出良好的选择性，不受同类生物标志物的影响。更有趣的是，已经设计了一种基于纸张的探测器。随着PGA含量的变化，纸基荧光探针会发生明显的从海军蓝到红色的荧光变化。通过与我们提出的纸基荧光探针相结合，也证明了在智能手机中使用彩色扫描应用程序进行定量分析的现场检测平台的实用性。本工作首次为PS生物标志物PGA的独立监测提供了一种快速、准确、灵敏的方法，并为结合智能手机设计便携、易操作的传感设备提供了一种新的思路。
The harm of plastic pollutants for human and environment is being paid more and more attention. Polystyrene (PS) and styrene are toxic compounds used in large quantities in the production of fiberglass reinforced polyesters. In this work, a simple method was designed for independent detecting polystyrene and styrene biomarker (phenylglyoxylic acid, PGA) in serum and urine. We prepared Eu3+ functionalized Sc-based metal organic frameworks as turn-on fluorescent switch for PGA. The distinct enhanced luminescence is observed from the Eu@MOFs with addition of PGA. The fabricated fluorescent switch has several appealing features including high sensitivity (LOD = 4.16 ppb), quick response time (less than 5 s) and broad linear range (0.02 mg/mL to 0.5 mg/mL). Furthermore, Eu@MOFs exhibits excellent selectivity that it is not affected by congeneric biomarkers. More interestingly, a paper-based probe has been devised. The paper-based fluorescence probe would perform an obvious fluorescence change from navy to red with the variety of PGA content. The practicability of the on-site detection platform for quantitative analysis using a colour scanning APP in smartphone has been also demonstrated by coupled with our proposed paper based fluorescence probe. This work first provides a fast, accurate and sensitive method for independent monitoring PS biomarker PGA, and the paper-based probe exhibit a new idea for design portable and easy to operate sensing devices combine with smartphone.