A clinically feasible 7-Tesla protocol for the identification of cortical lesions in Multiple Sclerosis
A clinically feasible 7-Tesla protocol for the identification of cortical lesions in Multiple Sclerosis
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DOI：
10.1007/s00330-020-06803-y
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发表时间：
2020-03-24
影响因子：
5.9
通讯作者：
Roccatagliata, Luca
中科院分区：
文献类型：
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作者：
Cocozza, Sirio;Cosottini, Mirco;Roccatagliata, Luca
目的本研究的目的是评价在7-T MRI扫描仪上获得的序列在适合临床研究的时间和解剖覆盖范围内识别多发性硬化（MS）患者皮质病变（CL）的能力。此外，我们的目的是确认CL的临床意义，测试灰质（GM）病变和临床评分之间的相关性。方法采用7-T磁共振成像，包括3D-T1加权和T2* 加权序列。由三位经验不同的阅片人独立评价图像，并记录CL数量。评估者之间的一致性，计算组内相关系数（ICC）。Lin的一致性相关系数用于比较序列之间的CL检测，而偏相关和多变量回归模型用于研究CL和临床数据之间的关系。结果40例MS患者（M/F，17/23; 44.7 ± 12.6岁）入组本研究，在35/40例受试者（87.5%）中确定了CL。3D-T1加权图像上的CL检出率与T2* 加权图像上的检出率显著相关（r = 0.99; p < 0.001），读片者之间具有高度一致性（ICC >= 0.995）。CL与运动和认知评分均显著相关（均P <0.05）。
Objectives The aim of this study was to evaluate the capability of sequences acquired on a 7-T MRI scanner, within times and anatomical coverage appropriate for clinical studies, to identify cortical lesions (CLs) in patients with Multiple Sclerosis (MS). Furthermore, we aimed to confirm the clinical significance of CL, testing the correlations between gray matter (GM) lesions and clinical scores. Methods A 7-T MRI protocol included 3D-T1-weighted and T2*-weighted sequences. Images were evaluated independently by three readers of different experience, and the number of CLs was recorded. Between-rater concordance was assessed calculating the intraclass correlation coefficient (ICC). Lin's concordance correlation coefficient was used to compare CL detection between sequences, while partial correlations and multivariable regression models were used to study the relationship between CL and clinical data. Results Forty MS patients (M/F, 17/23; 44.7 +/- 12.6 years) were enrolled in this study, and CLs were identified in 35/40 subjects (87.5%). CL detection rate on 3D-T1-weighted images was significantly correlated with the detection rate on T2*-weighted images (r = 0.99; p < 0.001), with high concordance between readers (ICC >= 0.995). CLs were significantly correlated with both motor and cognitive scores (all with p