The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries.
The use of power ultrasound coupled with magnetic separation for the solid phase synthesis of compound libraries.
复制标题
使用功率超声与磁力分离相结合进行化合物库的固相合成。
DOI：
10.1016/s0960-894x(99)00651-4
复制
发表时间：
2000
影响因子：
2.7
通讯作者：
Sucholeiki,I
中科院分区：
文献类型：
--
作者：
Perez,JM;Wilhelm,EJ;Sucholeiki,I
当功率超声被用作在顺磁性载体上的固相有机化学反应期间的混合的替代品时，观察到增强的反应速率。功率超声波也用于促进顺磁性载体的洗涤，因为顺磁性载体与反应混合物磁性分离。从库靶向κ-阿片受体的选择性的例子。
Enhanced reaction rates are observed when power ultrasound is utilized as a substitute for mixing during solid phase organic chemical reactions on a paramagnetic support. Power ultrasound is also used to facilitate the washing of the paramagnetic support as it is magnetically separated from the reaction mixture. Selective examples from a library targeting the κ-opioid receptor are presented.