Dualband spectral-spatial RF pulses for prostate MR spectroscopic imaging
Dualband spectral-spatial RF pulses for prostate MR spectroscopic imaging
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DOI：
10.1002/mrm.1302
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发表时间：
2001-12-01
影响因子：
3.3
通讯作者：
Vigneron, DB
中科院分区：
文献类型：
--
作者：
Schricker, AA;Pauly, JM;Vigneron, DB
尽管前列腺磁共振波谱成像 (MRSI) 已证明在癌症范围分期和监测方面具有临床实用性，但当前的采集方法在多个方面往往存在不足。传统的 180 度脉冲可能会出现化学位移重合失调的问题，并且具有高峰值功率要求，可能超出许多前列腺 MRSI 研究中的硬件限制。最佳的水和脂质抑制对于获得可解释的光谱也至关重要。虽然需要完全抑制前列腺周围脂质共振，但在治疗后无法检测到所有其他共振的情况下，控制水的部分抑制可以为数据分析和实验成功评估提供有价值的相位和频率参考。在这项研究中，开发了新的光谱空间 RIF 脉冲来消除化学位移重合误差，并提供双波段激发，部分激发水共振和完全激发感兴趣的代谢物。脉冲设计中还包含最佳相位调制，可将峰值射频功率降低 40%。使用新脉冲的患者研究证明了前列腺癌 MRSI 的可靠性和适用性的可行性和明显的好处。 (C) 2001 Wiley-Liss, Inc.
Although MR spectroscopic imaging (MRSI) of the prostate has demonstrated clinical utility for the staging and monitoring of cancer extent, current acquisition methods are often inadequate in several aspects. Conventional 180 degrees pulses can suffer from chemical shift misregistration, and have high peak-power requirements that can exceed hardware limits in many prostate MRSI studies. Optimal water and lipid suppression are also critical to obtain interpretable spectra. While complete suppression of the periprostatic lipid resonance is desired, controlled partial suppression of water can provide a valuable phase and frequency reference for data analysis and an assessment of experimental success in cases in which all other resonances are undetectable following treatment. In this study, new spectral-spatial RIF pulses were developed to negate chemical shift misregistration errors and to provide dualband excitation with partial excitation of the water resonance and full excitation of the metabolites of interest. Optimal phase modulation was also included in the pulse design to provide 40% reduction in peak RF power. Patient studies using the new pulses demonstrated both feasibility and clear benefits in the reliability and applicability of prostate cancer MRSI. (C) 2001 Wiley-Liss, Inc.