Evaluation of the Quality of Life and Health-Related Quality of Life of Patients With End-Stage Kidney Disease Resulting From Kidney Transplantation Using the Kidney Disease Quality of Life-Short Form and EuroQOL-5 Dimension-5 Level Questionnaires
Evaluation of the Quality of Life and Health-Related Quality of Life of Patients With End-Stage Kidney Disease Resulting From Kidney Transplantation Using the Kidney Disease Quality of Life-Short Form and EuroQOL-5 Dimension-5 Level Questionnaires
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DOI：
10.1016/j.transproceed.2020.09.018
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发表时间：
2021-03-27
影响因子：
0.9
通讯作者：
Kobayashi, Takashi
中科院分区：
文献类型：
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作者：
Sawada, Atsuro;Hiragi, Shusuke;Kobayashi, Takashi
背景资料。肾移植可改善终末期肾病(ESRD)合并肾功能衰竭患者的生活质量。然而，目前尚不清楚哪些肾脏疾病特有的生活质量因素决定了终末期肾病患者的一般健康相关生活质量。本研究旨在通过使用肾脏疾病生活质量简表(KDQOL-SF)1.3版和EuroQol-5维度-5水平(EQ-5D-5L)问卷对终末期肾病患者的生活质量进行测试，以确定这些生活质量项目。我们对本院67例肾移植受者进行了生活质量调查。评价一般健康相关生活质量的EQ-5D-5L为响应变量，KDQOL-SF包括肾脏疾病特定量表和一般健康相关生活质量SF-36量表为解释变量。采用皮尔逊相关系数分析KDQOL-SF各维度对EQ-5D-5L的影响。SF-36评定的一般健康相关生活质量中，躯体功能(R=0.749)和日常功能(R=0.603)等生理健康方面与EQ-5D-5L有较强的相关性，而心理和社会方面的相关较小。与肾脏疾病相关的症状和问题与EQ-5D-5L有较好的相关性(R=0.691)，而肾脏疾病负担(R=0.168)、社会交往质量(R=0.284)以及精神和社会方面的生活质量与EQ-5D-5L的相关性较低。在肾移植受者中，根据EQ-5D-5L的评估，生活质量的身体健康方面，如症状/问题，是影响总体生活质量的主要因素。
Background. Renal transplantation improves the quality of life (QOL) of end-stage renal disease (ESRD) patients with renal failure. However, it remains unclear which renal disease-specific QOL aspects determine general health-related QOL of ESRD patients. This study aimed to identify these QOL items by examining the QOL of ESRD patients using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), version 1.3, and EuroQoL-5 dimension-5 levels (EQ-5D-5L) questionnaires.Methods. We conducted QOL surveys with 67 renal transplant recipients at our hospital. EQ-5D-5L, which evaluates general health-related QOL, was the response variable, and KDQOL-SF, which includes the renal disease-specific instrument and general health-related QOL SF-36 instrument, was the explanatory variable. We analyzed the effects of each KDQOL-SF domain on EQ-5D-5L using Pearson correlation coefficient.Results. Regarding the general health-related QOL assessed by SF-36, physical health aspects, such as physical functioning (R = 0.749) and daily functioning physical (R = 0.603), showed a strong correlation with EQ-5D-5L, and the domains related to the psychological and social aspects of QOL showed a limited correlation. Regarding kidney disease-specific scales, symptoms/problems related to physical function showed a good correlation (R = 0.691) with EQ-5D-5L, whereas other scales, including burden of kidney disease (R = 0.168), quality of social interaction (R = 0.284), and those related to the mental and social aspects of QOL showed a low correlation with EQ-5D-5L.Conclusion. Among kidney transplant recipients, the physical health aspects of QOL, such as symptoms/problems, were the major factors influencing overall QOL as assessed by EQ-5D-5L.