Decreased first trimester uric acid production in future preeclamptic patients
Decreased first trimester uric acid production in future preeclamptic patients
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DOI：
10.1515/jpme.1997.25.4.347
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发表时间：
1997-01-01
影响因子：
2.4
通讯作者：
Dekker, GA
中科院分区：
文献类型：
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作者：
deJong, CLD;Paarlberg, KM;Dekker, GA
研究孕早期尿酸生成与妊娠高血压病（PIHD）后期发展的关系。尿酸的抗氧化作用已被提及。由于尿酸和纤维连接蛋白（PF）都是子痫前期的标志物，因此我们也研究了这两种物质之间的关系。选取对照组（n = 72）和PIHD患者（n = 120）。测定270例妊娠13 +/- 2周未生育妇女血清和24小时尿样（尿酸排泄）中的尿酸和血浆中的PF。在一组后来发展为PIHD的患者中，与血压正常的患者相比，尿酸排泄在妊娠早期显著降低（p < 0.05），尤其是在校正体重后（p < 0.01）。孕早期PF水平升高的患者尿酸排泄量明显低于PF水平正常的患者（p < 0.05）。数据显示，可能发生子痫前期的患者尿酸生成减少，这表明在妊娠早期抗氧化剂生成受损。这一观察结果与抗氧化剂和氧化剂之间的不平衡在子痫前期发病机制中起重要作用的假设很好地吻合。
The relationship between first trimester uric acid production and later development of pregnancy induced hypertensive disorders (PIHD) was investigated. An anti-oxidant role for uric acid has been mentioned. Since uric acid and fibronectin (PF) are both markers of preeclampsia, the relationship between these two substances was also studied.Controls (n = 72) and patients with PIHD (n = 120) were selected. Uric acid was measured in serum and 24-hours urine samples (uric acid excretion) and PF in blood plasma in 270 nulliparous women at 13 +/- 2 weeks of gestation.Uric acid excretion was significantly lower in the first trimester in a group of patients who later develop PIHD as compared to patients who remain normotensive (p < 0.05), especially when corrected for body weight (p < 0.01). Patients with elevated PF levels in the first trimester showed a significantly lower uric acid excretion than patients with normal PF levels (p < 0.05).The data show diminished uric acid production in patients who will likely develop preeclampsia suggesting an impaired anti-oxidant production in the first trimester This observation fits well with the hypothesis that an imbalance between anti-oxidant and oxidants prays an important role in the pathogenesis of preeclampsia.