Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction.
Myofibroblast Functions in Tissue Repair and Fibrosis: An Introduction.
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肌成纤维细胞在组织修复和纤维化中的功能：简介。
DOI：
10.1007/978-1-0716-1382-5_2
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Thannickal,VictorJ
中科院分区：
文献类型：
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作者：
Thannickal,VictorJ
在过去的二十年里，我们对肌成纤维细胞生物学的理解已经取得了进展，并且这些细胞在正常组织修复和纤维化疾病中的看似拮抗作用得到了更好的协调。与年龄相关的细胞可塑性丧失导致去分化和凋亡易感性能力受损，可能使个体易患涉及不同器官系统的非消退性和进行性纤维化疾病。
Our understanding of myofibroblast biology has advanced over the past two decades, and the seemingly antagonistic roles of these cells in both normal tissue repair and fibrotic diseases are better reconciled. An age-related loss of cellular plasticity that results in impaired capacity for de-differentiation and apoptosis susceptibility may predispose individuals to non-resolving and progressive fibrotic disorders involving diverse organ systems.