PTH and Vitamin D
PTH and Vitamin D
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DOI：
10.1002/cphy.c140071
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发表时间：
2016-04-01
影响因子：
5.8
通讯作者：
Lederer, Eleanor
中科院分区：
文献类型：
--
作者：
Khundmiri, Syed Jalal;Murray, Rebecca D.;Lederer, Eleanor
PTH和维生素D是矿物质代谢的两个主要调节剂。它们在维持钙和磷酸盐稳态以及骨骼健康的发育和维持中起着关键作用。PTH和维生素D形成严格控制的反馈循环，PTH是肾脏中维生素D合成的主要刺激物，而维生素D对PTH分泌产生负反馈。PTH的主要功能和主要生理调节剂是循环离子钙。PTH对肠道、肾脏和骨骼的作用是将血清钙维持在一个严格的范围内。PTH对磷酸盐代谢具有相互作用。相比之下，维生素D对钙和磷酸盐的体内平衡具有刺激作用，在为正常骨形成提供足够的矿物质方面发挥关键作用。这两种激素与最近发现的FGF23和klotho一致，这两种激素主要参与磷酸盐代谢，也参与这种紧密结合的反馈回路。最近的研究表明PTH和维生素D对心血管系统的影响非常有趣。甲状旁腺功能亢进和维生素D缺乏与多种心血管疾病有关，包括高血压、动脉粥样硬化、血管钙化和肾衰竭。这两种激素都对内皮、心脏和其他血管结构有直接影响。PTH和维生素D的这些作用如何与骨形成的调节相互作用是深入研究的主题。2016年出版。
PTH and Vitamin D are two major regulators of mineral metabolism. They play critical roles in the maintenance of calcium and phosphate homeostasis as well as the development and maintenance of bone health. PTH and Vitamin D form a tightly controlled feedback cycle, PTH being a major stimulator of vitamin D synthesis in the kidney while vitamin D exerts negative feedback on PTH secretion. The major function of PTH and major physiologic regulator is circulating ionized calcium. The effects of PTH on gut, kidney, and bone serve to maintain serum calcium within a tight range. PTH has a reciprocal effect on phosphate metabolism. In contrast, vitamin D has a stimulatory effect on both calcium and phosphate homeostasis, playing a key role in providing adequate mineral for normal bone formation. Both hormones act in concert with the more recently discovered FGF23 and klotho, hormones involved predominantly in phosphate metabolism, which also participate in this closely knit feedback circuit. Of great interest are recent studies demonstrating effects of both PTH and vitamin D on the cardiovascular system. Hyperparathyroidism and vitamin D deficiency have been implicated in a variety of cardiovascular disorders including hypertension, atherosclerosis, vascular calcification, and kidney failure. Both hormones have direct effects on the endothelium, heart, and other vascular structures. How these effects of PTH and vitamin D interface with the regulation of bone formation are the subject of intense investigation. Published 2016.