Vitamin D association with estradiol and progesterone in young women
Vitamin D association with estradiol and progesterone in young women
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DOI：
10.1007/s10552-009-9466-0
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发表时间：
2010-03-01
影响因子：
2.3
通讯作者：
Vieth, Reinhold
中科院分区：
文献类型：
--
作者：
Knight, Julia A.;Wong, Jody;Vieth, Reinhold
目的维生素D可能通过影响骑自行车妇女的类固醇激素来降低乳腺癌风险。我们进行了一项研究，以确定是否有一个协会之间的循环25-羟基维生素D（25（OH）D）和雌二醇和孕酮在年轻women.Methods志愿者妇女年龄在18-22岁，不使用激素避孕药在夏季和冬季招募。他们提供了人口统计和生活方式信息以及血液样本。冬季招募的妇女在服用维生素D补充剂4周后提供第二份样本。有101名妇女在黄体期（下一次月经开始前1-14天）取样。结果25（OH）D每增加10 nmol/l，孕酮每增加10%，孕酮每减少10%（95% CI 5- 14%，p < 0.001），雌二醇降低3%（95% CI 0- 6%，p = 0.04）校正年龄、体重指数、种族、季节、饮酒、吸烟、结论：较高水平的维生素D可能会降低孕酮和雌二醇，为年轻女性增加维生素D暴露降低乳腺癌风险提供了一种潜在的机制。
Objective Vitamin D may reduce breast cancer risk through an effect on steroid hormones in cycling women. We conducted a study to determine whether there is an association between circulating 25-hydroxyvitamin D (25(OH)D) and estradiol and progesterone in young women.Methods Volunteer women aged 18-22 and not using hormonal contraceptives were recruited during summer and winter. They provided demographic and lifestyle information and a blood sample. Women recruited in winter gave a second sample after taking vitamin D supplement for 4 weeks. There were 101 women sampled during the luteal phase (1-14 days prior to the start of the next menstrual period). Generalized estimating equation linear regression models were used to examine the relationship between 25(OH)D and estradiol and progesterone.Results Per increase of 10 nmol/l of 25(OH)D, progesterone multiplicatively decreased by a factor of 10% (95% CI 5-14%, p < 0.001) and estradiol decreased by a factor of 3% (95% CI 0-6%, p = 0.04) after adjustment for age, body mass index, ethnicity, season, alcohol use, smoking, and physical activity.Conclusions Higher levels of vitamin D may reduce progesterone and estradiol, providing a potential mechanism for reduction in breast cancer risk from increased vitamin D exposure in young women.