Single-cell growth and division dynamics showing epigenetic correlations.
Single-cell growth and division dynamics showing epigenetic correlations.
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DOI：
10.1039/b409860a
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发表时间：
2005-02
期刊：
影响因子：
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通讯作者：
Y. Wakamoto;J. Ramsden;K. Yasuda
中科院分区：
文献类型：
--
作者：
Y. Wakamoto;J. Ramsden;K. Yasuda
克隆细菌种群中出现的变异和随后出现的特征的遗传被认为是细胞中表观遗传过程的证据。我们报道了我们定量检测具有相同遗传天赋的单个大肠杆菌细胞的变异的实验结果，以确定单个细胞的某些特征是否被保持在统一环境中的后代所遗传。分叉时间、起始长和终止长在世代间存在较大差异。世代比较表明，间隔期与连续世代无相关性，初长和终长与相邻世代呈正相关。
The emergence of variation and subsequent inheritance of the emergent characteristics in a clonal population of bacteria is considered as evidence for epigenetic processes in the cell. We report here the results of experiments in which we quantitatively examined variations in single Escherichia coli cells with an identical genetic endowment in order to establish whether certain characteristics of single cells were inherited by their descendants maintained in a uniform environment. Significantly large variations of interdivision time, initial length, and final length were observed from generation to generation. Comparing the generations shows that interdivision time had no correlation with that of the consecutive generations, whereas those of initial length and final length were positively correlated with those of neighbouring generations.