THE CONTRIBUTION OF THE INFERIOR ENDOCARDIAL CUSHION OF THE ATRIOVENTRICULAR-CANAL TO CARDIAC SEPTATION AND TO THE DEVELOPMENT OF THE ATRIOVENTRICULAR VALVES - STUDY IN THE CHICK-EMBRYO
THE CONTRIBUTION OF THE INFERIOR ENDOCARDIAL CUSHION OF THE ATRIOVENTRICULAR-CANAL TO CARDIAC SEPTATION AND TO THE DEVELOPMENT OF THE ATRIOVENTRICULAR VALVES - STUDY IN THE CHICK-EMBRYO
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DOI：
10.1002/aja.1001660105
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
CAYRE, R
中科院分区：
文献类型：
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作者：
DELACRUZ, MV;GIMENEZRIBOTTA, M;CAYRE, R
用在体标记技术研究了鸡胚房室管下内膜垫对心脏分隔和房室瓣发育的作用。本研究在白色来航鸡胚胎中进行，其中在第20 - 21阶段（Hamburger和汉密尔顿，1951年）标记背垫，此时内膜垫尚未融合。在第35阶段处死胚胎这些实验使我们能够得出结论，下房室垫起源于：（a）二尖瓣前隔小叶的中隔插入点与纤维嵴之间的心脏中隔部分，相当于人类三尖瓣中隔小叶。（房室间隔）;（B）邻近房室间隔的房间隔和室间隔区域;（c）二尖瓣的前中隔瓣叶插入间隔的部分;（d）与三尖瓣隔叶相对应的纤维嵴，显微解剖显示，它们出现在18期时，房室管的上级和下内膜垫连续，无边界，心房和室间隔都有因此，每个房室口都通向相应的心室，鸡胚心脏的发育中不存在房室口同时与左心室相连的阶段，鸡和人的房室管的发育相似。
The contribution of the inferior endocardial cushion of the atrioventricular canal to cardiac septation and to the development of the atrioventricular valves was studied in the chick embryo by in vivo labelling techniques. The study was performed in White Leghorn chick embryos in which the dorsal cushion was labelled at stage 20‐21 (Hamburger and Hamilton, 1951), when the endocardial cushions were not yet fused. The embryos were sacrificed at stage 35 (mature heart).These experiments allow us to conclude that the inferior atrioventricular cushion gives origin to: (a) that part of the cardiac septum between the septal insertion of the antero‐septal leaflet of the mitral valve and the fibrous ridge which is the equivalent to the human septal leaflet of the tricuspid valve (atrioventricular septum); (b) the region of the interatrial and the interventricular septa adjacent to the atrioventricular septum; (c) the portion of the antero‐septal leaflet of the mitral valve which inserts into the septum; (d) the fibrous ridge corresponding to the septal leaflet of the tricuspid valve.Microdissection shows that, when they appear at stage 18, the superior and inferior endocardial cushions of the atrioventricular canal are in continuity, without boundaries, with both the interatrial and interventricular septa. Therefore, each atrioventricular orifice opens into its corresponding ventricle, there being no stage in the development of the chick embryo heart in which the atrioventricular orifices are connected to the left ventricle at the same time.The development of the atrioventricular canal is similar in the chick and human.