Hypotheses and controversies related to effects of stress on the hippocampus: An argument for stress-induced damage to the hippocampus in patients with posttraumatic stress disorder
Hypotheses and controversies related to effects of stress on the hippocampus: An argument for stress-induced damage to the hippocampus in patients with posttraumatic stress disorder
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DOI：
10.1002/hipo.1023
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发表时间：
2001-01-01
期刊：
影响因子：
3.5
通讯作者：
Bremner, JD
中科院分区：
文献类型：
--
作者：
Bremner, JD
回顾支持压力引起的神经系统损伤是创伤后应激障碍症状的基础这一理论的文献。动物研究表明，压力会导致海马损伤，人类PTSD研究表明，压力和PTSD的发展与海马萎缩和相关的记忆缺陷有关。有证据表明，这些影响是PTSD特异性的，而不是非特异性压力暴露影响或其他混杂因素（如酒精或药物滥用）的结果。应激诱导的糖皮质激素释放和其他因素可能参与其中。（PsycInfo数据库记录（c）2022阿帕，保留所有权利）
Reviews literature supporting the theory that stress-induced neurological damage underlies symptoms of% PTSD%. Animal studies have shown that stress can lead to hippocampal damage, and human PTSD studies have suggested that stress and PTSD development are associated with hippocampal atrophy and associated memory deficits. Evidence suggests that effects are PTSD-specific, and not the result of nonspecific stress exposure effects or other confounding factors such as alcohol or drug abuse. Stress-induced glucocorticoid release and other factors may be involved.(PsycInfo Database Record (c) 2022 APA, all rights reserved)