The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.
The role of microRNAs in Epstein-Barr virus latency and lytic reactivation.
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DOI：
10.1016/j.micinf.2011.07.007
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发表时间：
2011-12
影响因子：
5.8
通讯作者：
Luftig MA
中科院分区：
文献类型：
--
作者：
Forte E;Luftig MA
致癌病毒重新编程宿主基因表达，驱动增殖，确保生存，并逃避免疫反应。最近对microRNAs(MiRNAs)作为广泛调控基因表达的小非编码RNAs的认识为这一复杂的寄主控制机制提供了新的见解。这篇综述强调了病毒和细胞miRNAs在EBV生命周期潜伏期和裂解期的作用。
Oncogenic viruses reprogram host gene expression driving proliferation, ensuring survival, and evading the immune response. The recent appreciation of microRNAs (miRNAs) as small non-coding RNAs that broadly regulate gene expression has provided new insight into this complex scheme of host control. This review highlights the role of viral and cellular miRNAs during the latent and lytic phases of the EBV life cycle.