Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia
Isolation and evaluation of trypanocidal activity of sesquiterpenoids, flavonoids, and lignans in Artemisia sieversiana collected in Mongolia
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蒙古白蒿中倍半萜类化合物、黄酮类化合物和木脂素的分离及杀锥虫活性评价
DOI：
10.1007/s11418-020-01429-2
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发表时间：
2020
影响因子：
3.3
通讯作者：
Batkhuu Javzan
中科院分区：
文献类型：
--
作者：
Nurbek Stipan;Murata Toshihiro;Suganuma Keisuke;Ishikawa Yoshinobu;Buyankhishig Buyanmandakh;Kikuchi Takashi;Byambajav Tseesuren;Davaapurev Bekh-Ochir;Sasaki Kenroh;Batkhuu Javzan
摘要/ abstract摘要：黄貂草是一种一年生草本植物，分布在欧亚大陆中部和东部，在蒙古被认为是一种不受欢迎的饲料植物。它影响牲畜，因此需要有关其化学成分的信息。我们从ma中分离到3个新的倍半萜类化合物（1-3）和已知化合物。sieversiana调查了他们的活动。利用单晶x射线衍射晶体学建立了1的绝对构型，其构型与已有报道的结构相似的化合物不同。另外鉴定了两个结构相似的倍半萜类化合物（2和3），并确定了它们的构型。对分离得到的化合物（1 ~ 18）对刚果锥虫和动物致死性锥虫病病原体的杀虫活性进行了测定。黄酮类化合物和木脂素的ic50值在2.9 ~ 90.2µmg之间
AbstractArtemisia sieversianais an annual herbaceous plant distributed throughout Central and East Eurasia and is regarded as an undesirable forage plant in Mongolia. It affects livestock, so information about its chemical composition is needed. We isolated three new sesquiterpenoids (1–3) and known compounds fromA.sieversianaand investigated their activities. The absolute configuration of1was established using single-crystal X-ray diffraction crystallography, and its configuration differed from those of reported compounds with similar structures. Two additional new sesquiterpenoids (2and3) with similar structures were identified, and their configurations were determined. The trypanocidal activities of the isolated compounds (1–18) againstTrypanosoma congolenseand the pathogen responsible for fatal trypanosomosis in animals were estimated. Flavonoids and lignans were identified as active compounds with IC50values ranging from 2.9 to 90.2 µMGraphic abstract