The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism.
The Roles of Vitamin A in the Regulation of Carbohydrate, Lipid, and Protein Metabolism.
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DOI：
10.3390/jcm3020453
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发表时间：
2014-05-07
影响因子：
3.9
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Chen W;Chen G
目前，三分之二的美国成年人超重或肥胖。超重/肥胖的高流行率对人口的健康产生了负面影响，因为肥胖者往往会患上几种慢性病，如2型糖尿病和心血管疾病。由于肥胖对健康、医疗费用和寿命的影响，肥胖人数的增加已经成为一个公共卫生问题。遗传和环境/饮食因素在代谢性疾病的发展中都起着作用。直觉上，似乎很明显，过度营养与肥胖和其他代谢性疾病的发展有关。然而，潜在的机制仍不清楚。膳食营养素不仅提供来自大量营养素的能量，而且还提供具有调节作用的微量营养素等因素。微量营养素，如维生素A(VA；视黄醇)如何调节大量营养素的动态平衡仍然是一个正在进行的研究课题。作为一种必需的微量营养素，维生素A在个体的整体健康中起着关键作用。本文综述了维生素A在碳水化合物、脂肪和蛋白质代谢中作用的最新研究进展。由于有关VA功能的大量信息，本综述主要集中在代谢活跃的器官和组织中的代谢。此外，本文还将对未来的研究提供一些展望。
Currently, two-thirds of American adults are overweight or obese. This high prevalence of overweight/obesity negatively affects the health of the population, as obese individuals tend to develop several chronic diseases, such as type 2 diabetes and cardiovascular diseases. Due to obesity’s impact on health, medical costs, and longevity, the rise in the number of obese people has become a public health concern. Both genetic and environmental/dietary factors play a role in the development of metabolic diseases. Intuitively, it seems to be obvious to link over-nutrition to the development of obesity and other metabolic diseases. However, the underlying mechanisms are still unclear. Dietary nutrients not only provide energy derived from macronutrients, but also factors such as micronutrients with regulatory roles. How micronutrients, such as vitamin A (VA; retinol), regulate macronutrient homeostasis is still an ongoing research topic. As an essential micronutrient, VA plays a key role in the general health of an individual. This review summarizes recent research progress regarding VA’s role in carbohydrate, lipid, and protein metabolism. Due to the large amount of information regarding VA functions, this review focusses on metabolism in metabolic active organs and tissues. Additionally, some perspectives for future studies will be provided.