Schwann cells: Origins and role in axonal maintenance and regeneration
Schwann cells: Origins and role in axonal maintenance and regeneration
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DOI：
10.1016/j.biocel.2006.05.007
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发表时间：
2006-01-01
影响因子：
4
通讯作者：
Field, Jeffrey
中科院分区：
文献类型：
--
作者：
Bhatheja, Kanav;Field, Jeffrey
雪旺细胞在维持周围神经系统（PNS）方面发挥着至关重要的作用。雪旺细胞源自神经嵴细胞，有髓鞘雪旺细胞和非髓鞘雪旺细胞两种类型。两者在三七总皂苷神经元轴突的维持和再生中都发挥着关键作用。雪旺细胞的调节是由许多不同的神经营养因子介导的，这些因子向转录因子（如 Krox-20、Oct-6 和 Sox-10）发出信号。施万细胞受到许多脱髓鞘疾病的影响，例如夏科-马里-图思病和吉兰-巴利综合征，它们被麻风分枝杆菌感染导致麻风病，并导致 1 型神经纤维瘤病和 2 型神经纤维瘤病患者中出现的肿瘤。施万细胞正在研究作为脱髓鞘疾病和脊髓损伤的治疗剂。对雪旺细胞的进一步研究将有助于了解这些疾病，并可能带来新的治疗方法。 (c) 2006 Elsevier Ltd. 保留所有权利。
The Schwann cell plays a vital role in maintaining the peripheral nervous system (PNS). Schwann cells are derived from neural crest cells, and come in two types either myelinating or non-myelinating Schwann cells. Both play a pivotal role in the maintenance and regeneration of axons of the neurons in the PNS. The regulation of Schwann cells is mediated a number of different neurotrophic factors which signal to transcription factors such as Krox-20, Oct-6 and Sox-10. Schwann cells are affected in a number of demyelinating disorders, such as Charcot-Marie-Tooth disease and Guillain-Barre Syndrome, infected by Mycobacterium leprae to cause leprosy and are responsible for the tumors seen in patients with neurofibromatosis type 1 and neurofibromatosis type 2. The Schwann cell is under investigation as a therapeutic agent for demyelinating diseases and spinal cord injuries. Further research on Schwann cells will help understand these diseases and perhaps lead to new treatments. (c) 2006 Elsevier Ltd. All rights reserved.