Blue-Light Phase Shifts PER3 Gene Expression in Human Leukocytes
Blue-Light Phase Shifts PER3 Gene Expression in Human Leukocytes
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DOI：
10.1080/07420520902929045
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Skene, Debra J.
中科院分区：
文献类型：
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作者：
Ackermann, Katrin;Sletten, Tracey L.;Skene, Debra J.
在相位超前光刺激后研究了人类白细胞中时钟基因表达的时序，以确定响应是否与波长和/或年龄相关。分析单色蓝光和绿光照射前后白细胞和血浆褪黑激素中 PERIOD3 (PER3) 时钟基因的表达。在蓝光而非绿光照射后，PER3 表达和褪黑激素的峰值时间均观察到显着的相位提前。基线时 PER3 节律的振幅随着年龄的增长而显着降低。然而，年龄并不影响PER3节律对光的反应。 （作者通讯：d.skene@surrey.ac.uk）。
The timing of clock gene expression in human leukocytes was investigated following a phase-advancing light stimulus to determine whether the response is wavelength- and/or age-dependent. PERIOD3 (PER3) clock gene expression in leukocytes and plasma melatonin were analyzed before and after monochromatic blue and green light exposure. Significant phase advances were observed in the peak timing of both PER3 expression and melatonin following blue but not green light. The amplitude of the PER3 rhythm at baseline was significantly reduced with age. However, age did not affect the response of the PER3 rhythm to light. (Author correspondence: d.skene@surrey.ac.uk).