Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: Glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine
Effects of sub-lethal exposure of rats to the herbicide glyphosate in drinking water: Glutathione transferase enzyme activities, levels of reduced glutathione and lipid peroxidation in liver, kidneys and small intestine
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DOI：
10.1016/j.etap.2012.09.005
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发表时间：
2012-11-01
影响因子：
4.3
通讯作者：
Virkel, G.
中科院分区：
文献类型：
--
作者：
Larsen, K.;Najle, R.;Virkel, G.
草甘膦（GLP）是一种广谱除草剂，是许多除草剂的活性成分。Wistar大鼠在30或90天内暴露于人类饮用水中允许的最高水平GLP（0.7 mg/L）（美国环保局，2011年）和高出10倍的浓度（7 mg/L）。暴露于除草剂的低水平没有产生组织形态学变化。与未暴露于除草剂的对照动物相比，TBARS的产生类似或倾向于较低。在暴露于GLP的大鼠中，还原型谷胱甘肽（GSH）水平升高和谷胱甘肽过氧化物酶（GPx）活性增强可能是对抗除草剂可能有害影响的保护机制。总体而言，这项工作显示出某些生化变化，即使GLP剂量比口服参考剂量2 mg/kg/天低3-20倍（US EPA，1993）。这些发现的毒理学意义仍有待澄清。(C)2012爱思唯尔有限公司版权所有。
Glyphosate (GLP), the active ingredient of many weed killing formulations, is a broad spectrum herbicide compound. Wistar rats were exposed during 30 or 90 days to the highest level (0.7 mg/L) of GLP allowed in water for human consumption (US EPA, 2011) and a 10-fold higher concentration (7 mg/L). The low levels of exposure to the herbicide did not produce histomorphological changes. The production of TBARS was similar or tended to be lower compared to control animals not exposed to the herbicide. In rats exposed to GLP, increased levels of reduced glutathione (GSH) and enhanced glutathione peroxidase (GPx) activity may act as a protective mechanism against possible detrimental effects of the herbicide. Overall, this work showed certain biochemical modifications, even at 3-20-fold lower doses of GLP than the oral reference dose of 2 mg/kg/day (US EPA, 1993). The toxicological significance of these findings remains to be clarified. (C) 2012 Elsevier B.V. All rights reserved.