Probiotics - Role in inflammatory bowel disease
Probiotics - Role in inflammatory bowel disease
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DOI：
10.1016/s1590-8658(02)80166-9
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发表时间：
2002-09-01
影响因子：
4.5
通讯作者：
Campieri, M
中科院分区：
文献类型：
--
作者：
Gionchetti, P;Amadini, C;Campieri, M
炎症性肠病的病因学仍然不清楚，虽然尚未发现与这些疾病相关的特定病原体，但炎症性肠病中益生菌治疗的基本原理是基于令人信服的证据，这些证据涉及肠道细菌在其发病机制中。在几种实验性结肠炎动物模型中，益生菌疗法已经获得了令人鼓舞的结果。高浓度益生菌制剂的施用代表了预防结肠袋炎发作和复发的有效方法。在溃疡性结肠炎和克罗恩病中获得的令人鼓舞的结果需要在大型双盲试验中进一步评估。
The aetiology of inflammatory bowel disease is still unclean Whilst a specific pathogen agent associated with these diseases has not been found, the rationale for probiotic therapy in inflammatory bowel disease is based on convincing evidence involving intestinal bacteria in their pathogenesis. Encouraging results have been obtained with probiotic therapy in several animal models of experimental colitis. The administration of highly concentrated probiotic preparations represents a valid approach both for the prevention of pouchitis onset and relapses. The encouraging results obtained in ulcerative colitis and Crohn's disease need to be further assessed in large double-blind trials.