Serum sodium levels in patients with Kawasaki disease
Serum sodium levels in patients with Kawasaki disease
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DOI：
10.1007/s00246-004-0789-z
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发表时间：
2005-07-01
影响因子：
1.6
通讯作者：
Matsuishi, T
中科院分区：
文献类型：
--
作者：
Muta, H;Ishii, M;Matsuishi, T
本研究的目的是评估低血清钠水平与川崎患者心血管后遗症相关的假设。我们使用了日本第16次全国KD调查的数据库。我们调查了血清钠水平的分布以及血清钠水平与心血管后遗症之间的关系。在报告的病例中，13，569例患者（89%）报告了血清钠水平。完全病例中血清钠水平≤ 130 mEq/L的患者比例高于不完全病例。血清钠水平≤ 130 mEq/L的患者比例随年龄增加而增加。发病后3-5天内血清钠水平≤ 130 mEq/L的患者比例最大。血清钠水平135 mEq/L或更低是心血管后遗症的独立风险因素（比值比，1.79，95%置信区间，1.42-2.26）。在KD患者中，血清钠水平在诊断类别、年龄和发病后天数之间存在显著差异。钠水平可能是心血管后遗症的简单预测因子。
The purpose of this study was to assess the hypothesis that lower serum sodium levels are associated with cardiovascular sequelae in patients with Kawasaki disease (KD). We used the database of the 16th nationwide survey of KD in Japan. We investigated the distribution of serum sodium levels and the relationship between serum sodium levels and cardiovascular sequelae. Of the reported cases, serum sodium levels were reported in 13,569 patients (89%). The proportion of patients with serum sodium levels 130 mEq/L or less, was greater in complete cases than in incomplete cases. The proportion of patients with serum sodium levels 130 mEq/L or less was increased with age. The largest proportion of patients with serum sodium levels 130 mEq/L or less was found in the category of 3-5 days since onset of illness. A serum sodium of level 135 mEq/L or less was an independent risk factor for cardiovascular sequelae (odds ratio, 1.79, 95% confidence interval, 1.42-2.26). Among patients with KD, there are significant differences in serum sodium levels between diagnostic categories, age, and days since the onset of illness. The sodium level may be a simple predictor of cardiovascular sequelae.