Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation
Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation
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DOI：
10.1126/science.1066273
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发表时间：
2001-11-16
期刊：
影响因子：
56.9
通讯作者：
Hawkins, RD
中科院分区：
文献类型：
--
作者：
Antonova, I;Arancio, O;Hawkins, RD
神经元间突触通讯效率的变化被认为是学习的基础。与最近对这种变化的研究一致，我们发现培养海马神经元之间突触传递的长味觉增强伴随着含有GLuR1亚基的突触后谷氨酸受体簇数量的增加。此外，增强还伴随着突触前蛋白synaptophysin簇数量的快速和长时间的增加，以及synaptophysin和GLuR1共定位的位点数量的增加。这些结果表明，增强涉及突触前神经元和突触后神经元中蛋白质分布的快速协调变化。
A change in the efficiency of synaptic communication between neurons is thought to underlie learning. Consistent with recent studies of such changes, we find that long-tasting potentiation of synaptic transmission between cultured hippocampal neurons is accompanied by an increase in the number of clusters of postsynaptic glutamate receptors containing the subunit GLuR1. In addition, potentiation is accompanied by a rapid and long-tasting increase in the number of clusters of the presynaptic protein synaptophysin and the number of sites at which synaptophysin and GLuR1 are colocalized. These results suggest that potentiation involves rapid coordinate changes in the distribution of proteins in the presynaptic neuron as well as the postsynaptic neuron.