Marine Natural Products: A Source of Novel Anticancer Drugs
Marine Natural Products: A Source of Novel Anticancer Drugs
复制标题
DOI：
10.3390/md17090491
复制
发表时间：
2019-09-01
期刊：
影响因子：
5.4
通讯作者：
El-Seedi, Hesham R.
中科院分区：
文献类型：
--
作者：
Khalifa, Shaden A. M.;Elias, Nizar;El-Seedi, Hesham R.
癌症仍然是世界上最致命的疾病之一。迫切需要具有新作用模式的新药，因此已经对来自天然来源，特别是植物、微生物和海洋生物的新抗癌药物进行了大量研究。海洋种群是具有不同化学结构的新型生物活性代谢物的储存库。这篇评论强调了海洋生物的影响，特别强调海洋植物、藻类、细菌、放线菌、真菌、海绵和软珊瑚。首次介绍了海洋天然产物的体外和体内抗癌作用研究;探讨了其预防肿瘤形成的活性以及相关化合物诱导的细胞凋亡和细胞毒性。生物学效应背后可能的分子机制也被提出。综述了海洋生物的多样性、新颖的化学结构和化学性质空间。最后，治疗策略和目前使用的海洋衍生成分，其未来的发展方向和局限性进行了讨论。
Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.