Dry eye after laser in situ keratomileusis with femtosecond laser and mechanical keratome
Dry eye after laser in situ keratomileusis with femtosecond laser and mechanical keratome
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DOI：
10.1016/j.jcrs.2011.03.035
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发表时间：
2011-08-01
影响因子：
2.8
通讯作者：
Manche, Edward E.
中科院分区：
文献类型：
--
作者：
Golas, Liliya;Manche, Edward E.
目的：前瞻性比较激光原位角膜磨除术（LASIK）与机械角膜磨除术和飞秒激光角膜磨除术术后干眼症状。单位：美国加州斯坦福大学医学院眼科。设计：随机临床试验。方法：随机分为机械角膜移植术组和飞秒激光角膜移植术组。患者接受波前引导LASIK手术，一只眼使用机械角膜移植术，另一只眼使用飞秒激光角膜移植术。他们分别在术前、术后1、3、6、12个月完成干眼症问卷调查。分析激光消融深度、性别、年龄、皮瓣厚度对干眼症状的影响。结果：该研究纳入了51例患者。除飞秒组术后1个月干眼症状变化（平均增加1.08）外，无统计学意义（P= 0.03）。两组患者症状差异无统计学意义（P=.7）。女性的干眼评分比男性低1.3分（P= 0.01）。中心消融深度、皮瓣厚度和年龄对报告的干燥无显著影响。结论：机械角膜移植术组与飞秒激光角膜移植术组在干眼症状自述上无统计学差异。
PURPOSE: To prospectively compare dry-eye symptoms after laser in situ keratomileusis (LASIK) with mechanical keratome created flaps and femtosecond laser keratome created flaps.SETTING: Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA.DESIGN: Randomized clinical trial.METHODS: Fellow eyes were prospectively randomized to the mechanical keratome group and femtosecond laser keratome group. Patients had wavefront-guided LASIK using a mechanical keratome in 1 eye and a femtosecond laser keratome in the fellow eye. They completed dry-eye questionnaires preoperatively and 1, 3, 6, and 12 months postoperatively. The effect of laser ablation depth, sex, age, and flap thickness on dry-eye symptoms was also analyzed.RESULTS: The study enrolled 51 patients. There was no statistically significant change in dry-eye symptoms except in the femtosecond group 1 month postoperatively (mean increase 1.08) (P=.03). There were no significant differences in symptoms between the 2 groups (P=.7). The dry-eye score was 1.3 points lower in women than in men (P=.01). Central ablation depth, flap thickness, and age did not significantly affect the reported dryness.CONCLUSION: There appeared to be no statistically significant difference in self-reported dry-eye symptoms between the mechanical keratome group and the femtosecond laser keratome group.