Sleep restriction effects on sleep spindles in adolescents and relation of these effects to subsequent daytime sleepiness and cognition.
Sleep restriction effects on sleep spindles in adolescents and relation of these effects to subsequent daytime sleepiness and cognition.
复制标题
睡眠限制对青少年睡眠纺锤波的影响以及这些影响与随后的白天嗜睡和认知的关系。
DOI：
10.1093/sleep/zsad071
复制
发表时间：
2023
期刊：
影响因子：
5.6
通讯作者：
Grimm,KevinJ
中科院分区：
文献类型：
--
作者：
Campbell,IanG;Zhang,ZoeyY;Grimm,KevinJ
研究目的通过睡眠限制来限制纺锤波活动可以解释青少年睡眠不足的一些负面认知影响。目前的研究评估了睡眠限制如何影响睡眠纺锤波的数量、发生率、振幅、持续时间和波频率，并测试了睡眠限制对纺锤波的影响是否会在青春期发生变化。该研究确定是否睡眠限制影响白天嗜睡，警惕性和认知有关的睡眠纺锤波的变化。MethodsIn每年的这3年的纵向研究，77名参与者，年龄范围从10至16岁，每个完成三个不同的时间在床上（TIB）的时间表：7，8.5，或10小时在床上连续4晚。一种计算机算法检测和分析了第四夜中央和额叶脑电的睡眠纺锤波。客观和自我报告的白天嗜睡和认知进行了评估的第4 night.Results7与10小时TIB平均通宵额叶和中央纺锤体计数分别减少了35%和32%，分别。减少TIB也显着降低纺锤波发生率在前5个小时的非快速眼动睡眠，产生小但显着减少纺锤波振幅，并有很少或没有影响的纺锤波持续时间和纺锤波频率。睡眠限制的影响并不随年龄而改变。纺锤体计数和发病率的减少与第二天的白天嗜睡有关，但与工作memory.ConclusionsThe睡眠丧失对青少年白天功能的影响部分介导的减少睡眠纺锤体影响白天嗜睡。
Study ObjectivesLimiting spindle activity via sleep restriction could explain some of the negative cognitive effects of sleep loss in adolescents. The current study evaluates how sleep restriction affects sleep spindle number, incidence, amplitude, duration, and wave frequency and tests whether sleep restriction effects on spindles change across the years of adolescence. The study determines whether sleep restriction effects on daytime sleepiness, vigilance, and cognition are related to changes in sleep spindles.MethodsIn each year of this 3-year longitudinal study, 77 participants, ranging in age from 10 to 16 years, each completed three different time in bed (TIB) schedules: 7, 8.5, or 10 hours in bed for 4 consecutive nights. A computer algorithm detected and analyzed sleep spindles in night four central and frontal electroencephalogram. Objective and self-reported daytime sleepiness and cognition were evaluated on the day following the 4th night.ResultsFor 7 versus 10 hours TIB average all-night frontal and central spindle counts were reduced by 35% and 32%, respectively. Reducing TIB also significantly decreased spindle incidence in the first 5 hours of non-rapid eye movement sleep, produced small but significant reductions in spindle amplitude, and had little to no effect on spindle duration and spindle wave frequency. Sleep restriction effects did not change with age. The reductions in spindle count and incidence were related to daytime sleepiness on the following day but were not related to working memory.ConclusionsThe sleep loss effects on daytime functioning in adolescents are partially mediated by reduced sleep spindles impacting daytime sleepiness.