Lipoprotein profile and cholesteryl ester transfer protein in neonates
Lipoprotein profile and cholesteryl ester transfer protein in neonates
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DOI：
10.1053/meta.2001.23307
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发表时间：
2001-06-01
影响因子：
9.8
通讯作者：
Patsch, JR
中科院分区：
文献类型：
--
作者：
Kaser, S;Ebenbichler, CF;Patsch, JR
子宫内营养不良似乎与代谢、内分泌和免疫功能的持续变化有关。在这项研究中，我们确定了出生体重对脂蛋白谱和胆固醇酯转移蛋白（CETP）的影响，CETP通过确定各自脂蛋白颗粒的化学，物理和生物学特性促进血浆中致动脉粥样硬化的脂蛋白谱。小于胎龄儿（SGA）的甘油三酯（TG）浓度最高，高密度脂蛋白（HDL）（2）-胆固醇水平最低，CETP-质量用酶联免疫吸附测定（ELISA）测定，CETP-活性用外源性脂蛋白测定，胆固醇酯转移测定为放射性标记的胆固醇酯（CE）从HDL转移到含载脂蛋白B的脂蛋白，SGA新生儿CETP质量最低，胆固醇酯转移最高，CETP活性在新生儿之间没有差异。我们的研究结果表明，增加和减少营养在子宫内影响脂蛋白谱和CETP的新生儿，高TG和低HDL，在SGA新生儿水平可能是由于增加胆固醇酯转移，并可能部分解释了增加的风险，冠心病（CHD）的小于胎龄儿在以后的生活。Copyright（C）2001 by W.B.桑德斯公司
Undernourishment in utero appears to be associated with persisting changes in the metabolic, endocrine, and immune functions. In this study, we determined the influence of birth weight on the lipoprotein profile and cholesteryl ester transfer protein (CETP), which promotes a proatherogenic lipoprotein profile in plasma by determining the chemical, physical, and biologic properties of the respective lipoprotein particles. Triglyceride (TG) concentrations were highest and high-density lipoprotein (HDL)(2)-cholesterol levels were lowest in small for gestational age (SGA) neonates, CETP-mass was determined by enzyme-linked immunosorbent assay (ELISA) and CETP-activity by using exogenous lipoproteins, Cholesteryl ester transfer was determined as transfer of radiolabeled cholesteryl esters (CE) from HDL to apolipoprotein B-containing lipoproteins, CETP mass was lowest and cholesteryl ester transfer was highest in SGA neonates, CETP-activity did not differ among the neonates. Our results suggest that increased and decreased nourishment in utero affects the lipoprotein profile and CETP in neonates, High TG and low HDL, levels in SGA neonates might result from increased cholesteryl ester transfer and, may in part, explain the increased risk of coronary heart disease (CHD) of small for gestational age neonates in later life. Copyright (C) 2001 by W.B. Saunders Company.