Acupuncture relieves menopausal discomfort in breast cancer patients: A prospective, double blinded, randomized study
Acupuncture relieves menopausal discomfort in breast cancer patients: A prospective, double blinded, randomized study
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DOI：
10.1016/j.breast.2012.07.015
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发表时间：
2013-06-01
期刊：
影响因子：
3.9
通讯作者：
Flyger, Henrik
中科院分区：
文献类型：
--
作者：
Bokmand, Susanne;Flyger, Henrik
背景：这项研究评估了针灸对乳腺癌患者潮热和夜间睡眠障碍的影响。针刺效果与假针刺组和未治疗对照组进行比较。测定血浆雌二醇，以排除这是原因。方法：我们随机将94名女性纳入研究：31名接受针灸，29名接受假针灸，34名没有接受治疗。结果：针刺组有16名患者(52%)出现明显的潮热症状，而假针刺组有7名患者(24%)出现明显的潮热症状(p<；0.05)。这种效果是在第二次针灸治疗后出现的，并在最后一次治疗后持续至少12周。与假针刺组和未治疗组相比，针刺组对睡眠的改善有统计学意义的正效应。这种效果与血浆雌二醇水平的升高无关。没有记录针灸的副作用。解释：我们发现针灸显著缓解潮热和睡眠障碍，是治疗乳腺癌的女性的一种良好且安全的治疗方法。该项目已在临床试验网站注册(编号：NCT00425776)。(C)2012爱思唯尔有限公司。保留所有权利。
Background: This study evaluates the effect of acupuncture on hot flashes and disturbed night sleep in patients treated for breast cancer. The effect of acupuncture was tested against a sham-acupuncture group and a no-treatment control group. Plasma estradiol was measured to rule out this as cause of effect. Side effects of the treatment were registered.Methods: We randomized 94 women into the study: 31 had acupuncture, 29 had sham acupuncture and 34 had no treatment.Findings: In the acupuncture group, 16 patients (52%) experienced a significant effect on hot flashes compared with seven patients (24%) in the sham group (p < 0.05). The effect came after the second acupuncture session and lasted for at least 12 weeks after last treatment. A statistically significant positive effect was seen on sleep in the acupuncture group compared with the sham-acupuncture and no-treatment groups. The effect was not correlated with increased levels of plasma estradiol. No side effects of acupuncture were registered.Interpretation: We find that acupuncture significantly relieves hot flashes and sleep disturbances and is a good and safe treatment in women treated for breast cancer.The project is registered at Clinical Trials.gov (no: NCT00425776). (C) 2012 Elsevier Ltd. All rights reserved.