Diastolic wall strain is associated with incident heart failure in African Americans: Insights from the atherosclerosis risk in communities study.
Diastolic wall strain is associated with incident heart failure in African Americans: Insights from the atherosclerosis risk in communities study.
复制标题
舒张室壁应变与非裔美国人的心力衰竭有关：社区研究中动脉粥样硬化风险的见解。
DOI：
10.1016/j.jjcc.2017.11.004
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Mosley,ThomasH
中科院分区：
文献类型：
--
作者：
Kamimura,Daisuke;Suzuki,Takeki;Hall,MichaelE;Wang,Wanmei;Winniford,MichaelD;Shah,AmilM;Rodriguez,CarlosJ;Butler,KennethR;Mosley,ThomasH
BackgroundIncreased left ventricular (LV) myocardial stiffness may be associated with impaired LV hemodynamics and incident heart failure (HF). However, an indicator that estimates LV myocardial stiffness easily and non-invasively is lacking. The purpose of this study was to determine whether diastolic wall strain (DWS), an echocardiographic estimator of LV myocardial stiffness, is associated with incident HF in a middle-aged community-based cohort of African Americans.Methods and resultsWe investigated associations between DWS and incident HF among 1528 African Americans (mean age 58.5 years, 66% women) with preserved LV ejection fraction (EF ≥50%) and without a history of cardiovascular disease in the Atherosclerosis Risk in Communities Study. Participants with the smallest DWS quintile (more LV myocardial stiffness) had a higher LV mass index, higher relative wall thickness, and lower arterial compliance than those in the larger four DWS quintiles (p< 0.01 for all). Over a mean follow-up of 15.6 years, there were 251 incident HF events (incidence rate: 10.9 per 1000 person-years). After adjustment for traditional risk factors and incident coronary artery disease, both continuous and categorical DWS were independently associated with incident HF (HR 1.21, 95%CI 1.04–1.41 for 0.1 decrease in continuous DWS,p= 0.014, HR 1.40, 95%CI 1.05–1.87 for the smallest DWS quintile vs other combined quintiles,p= 0.022).ConclusionsDWS was independently associated with an increased risk of incident HF in a community-based cohort of African Americans. DWS could be used as a qualitative estimator of LV myocardial stiffness.
