Adrenocortical responses to submaximal exercise in postmenopausal black and white women.
Adrenocortical responses to submaximal exercise in postmenopausal black and white women.
复制标题
绝经后黑人和白人女性肾上腺皮质对次最大运动的反应。
DOI：
10.1016/s0026-0495(03)00312-3
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Kanaley,JA
中科院分区：
文献类型：
--
作者：
Giannopoulou,I;Carhart,R;Sauro,LM;Kanaley,JA
本研究的目的是确定是否存在种族差异的脱氢表雄酮（DHEA），硫酸脱氢表雄酮（DHEAS），皮质醇浓度的黑人和白色绝经后妇女在休息和响应次极量运动。对23名绝经后妇女（13名白色和10名黑人）进行了两次研究。一次受试者安静地休息4小时（对照日），而在另一次休息50分钟后，受试者在自行车测力计上以70%的Vo 2峰值运动30分钟（运动日）。在休息时、运动时和恢复时采集血样，测定DHEA、DHEAS和皮质醇浓度。黑人和白色女性的静息DHEA和皮质醇浓度以及积分曲线下面积（AUC）相似;然而，黑人女性的静息DHEAS浓度低于白色女性（DHEAS，黑人：1.32 ± 0.29 vs白色：2.18 ± 0.25 μmol · L-1，P <0.05）。无论种族如何，DHEA和皮质醇的AUC显著高于静息值（P <0.01），但黑人和白色女性的DHEA和皮质醇的运动AUC没有差异（DHEA：607 ± 133和824 ± 108 min × nmol · L-1;皮质醇：9，604 ± 1，247和8，076 ± 1，093 min × nmol · L-1）。在两组中均未发现运动诱导的DHEAS AUC积分变化。总之，绝经后妇女的静息DHEAS水平存在种族差异，但静息DHEA和皮质醇浓度无种族差异。种族对这些肾上腺激素对次极量运动的反应没有影响。
The purpose of this study was to determine whether racial differences exist in the dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEAS), and cortisol concentrations of black and white postmenopausal women at rest and in response to submaximal exercise. Twenty-three postmenopausal women (13 white and 10 black) were studied on 2 occasions. On one occasion subjects rested quietly for 4 hours (control day), whereas on the other occasion after 50 minutes of rest, subjects exercised at 70% of Vo2peak for 30 minutes on a cycle ergometer (exercise day). Blood was sampled at rest, during exercise, and during recovery and assayed for DHEA, DHEAS, and cortisol concentrations. Resting DHEA and cortisol concentrations and integrated area under the curve (AUC) were similar between the black and white women; however, the black women had lower resting DHEAS concentrations compared with the white women (DHEAS, black: 1.32 ± 0.29 v white: 2.18 ± 0.25 μmol · L−1, P < .05). Regardless of race, DHEA and cortisol AUC increased significantly above resting values (P < .01), but the exercise AUC for DHEA and cortisol were not different between the black and white women (DHEA: 607 ± 133 and 824 ± 108 min × nmol · L−1; cortisol: 9,604 ± 1,247 and 8,076 ± 1,093 min × nmol · L−1, respectively). No exercise-induced change in integrated DHEAS AUC was found in either group. In conclusion, racial differences exist in the resting DHEAS levels of postmenopausal women, but with no racial differences in resting DHEA and cortisol concentrations. Race had no impact on these adrenal hormone responses to submaximal exercise.