Adenosine inhibits locus coeruleus neurons: an intracellular study in a rat brain slice preparation.
Adenosine inhibits locus coeruleus neurons: an intracellular study in a rat brain slice preparation.
复制标题
腺苷抑制蓝斑神经元：大鼠脑切片制备的细胞内研究。
DOI：
10.1016/0006-8993(86)91320-x
复制
发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
Chiu,TH
中科院分区：
文献类型：
--
作者：
Shefner,SA;Chiu,TH
Intracellular recording was used to study the effect of adenosine (3–100 μM) on rat locus coeruleus (LC) neurons in a brain slice preparation. Bath application of adenosine (100 μM) reduced the rate of spontaneous firing in 88% of LC neurons. In some LC neurons adenosine also caused membrane hyperpolarization (2–10 mV) and reductions in input resistance of 9–24%. Adenosine effects were dose-dependent and antagonized by the adenosine receptor antagonist theophylline.
