Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.
Increased neutrophil-to-lymphocyte ratio is associated with disease-specific mortality in patients with penile cancer.
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嗜中性粒细胞与淋巴细胞比率与阴茎癌患者的疾病特异性死亡率有关。
DOI：
10.1186/s12885-016-2443-6
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发表时间：
2016-07-07
期刊：
影响因子：
3.8
通讯作者：
Uemura H
中科院分区：
文献类型：
--
作者：
Kasuga J;Kawahara T;Takamoto D;Fukui S;Tokita T;Tadenuma T;Narahara M;Fusayasu S;Terao H;Izumi K;Ito H;Hattori Y;Teranishi J;Sasaki T;Makiyama K;Miyoshi Y;Yao M;Yumura Y;Miyamoto H;Uemura H
中性粒细胞与淋巴细胞比率（NLR）是全身炎症反应的简单标志，已被证明与各种实体恶性肿瘤的患者预后相关。我们研究了治疗前 NLR 作为阴茎癌患者预后指标的效用。研究人员对 1988 年至 2014 年间接受全血细胞计数和分类以及随后的根治性阴茎切除术的总共 41 名患者进行了分析。我们评估了 NLR 与阴茎癌预后之间的相关性。 41 名阴茎癌患者的中位和平均 (± SD) NLR 分别为 3.42 和 5.03±4.99。根据受试者工作特征曲线下面积，确定 NLR 的截止值为 2.82。高 NLR (≥2.82) 的患者的癌症特异性生存率明显低于低 NLR 的患者 (p = 0.023)。治疗前的 NLR 可能作为精确预测阴茎癌患者预后的生物标志物。
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer. A total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer. The median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR. The pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.