Ethnic differences in thromboprophylaxis for COVID-19 patients: should they be considered?
Ethnic differences in thromboprophylaxis for COVID-19 patients: should they be considered?
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DOI：
10.1007/s12185-021-03078-x
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发表时间：
2021-03
影响因子：
2.1
通讯作者：
Levy JH
中科院分区：
文献类型：
--
作者：
Iba T;Connors JM;Spyropoulos AC;Wada H;Levy JH
血栓栓塞事件导致2019冠状病毒病（COVID-19）的发病率和死亡率。因此，根据多项指南，普遍推荐住院患者使用低分子肝素（LMWH）进行血栓预防。然而，在血栓形成性方面的种族差异已被报道，并且血栓栓塞事件的发生率被认为在亚洲人群中较低。尽管血栓预防的重要性，出血也是一个应该考虑的副作用。我们研究了与COVID-19患者血栓形成和出血的潜在种族差异相关的数据。虽然还没有足够的数据，但根据我们的综述，目前的证据并不反对对入院患者使用标准剂量的低分子肝素进行常规抗凝剂和血栓预防，而不考虑种族。
Thromboembolic events contribute to morbidity and mortality in coronavirus disease 2019 (COVID-19). As a result, thromboprophylaxis using low-molecular-weight heparin (LMWH) is universally recommended for hospitalized patients based on multiple guidelines. However, ethnic differences with respect to thrombogenicity have been reported and the incidence of thromboembolic events is considered to be lower in the Asian population. Despite the importance of thromboprophylaxis, bleeding is also a side effect that should be considered. We examine the data relating to potential ethnic differences in thrombosis and bleeding in COVID-19. Although sufficient data is not yet available, current evidence does not oppose routine anticoagulant use and thromboprophylaxis using a standard dose of LMWH for admitted patients regardless of ethnicity based on our review.
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