The Cognitive Role of the Globus Pallidus interna; Insights from Disease States.
The Cognitive Role of the Globus Pallidus interna; Insights from Disease States.
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DOI：
10.1007/s00221-017-4905-8
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发表时间：
2017-05
影响因子：
2
通讯作者：
Green AL
中科院分区：
文献类型：
--
作者：
Gillies MJ;Hyam JA;Weiss AR;Antoniades CA;Bogacz R;Fitzgerald JJ;Aziz TZ;Whittington MA;Green AL
帕金森病和局灶性肌张力障碍的运动症状均由基底神经节功能障碍引起，可通过苍白球切开术或内苍白球 (GPi) 的深部脑刺激得到改善。然而，与肌张力障碍相比，帕金森病与基底神经节依赖性学习障碍的相关程度更大。我们试图通过比较两种情况下基底神经节输出的电生理学来理解这一观察结果。我们使用深部脑刺激提供的自然实验来比较帕金森病受试者与肌张力障碍受试者在执行带有感觉反馈的强制选择决策任务时的 GPi 局部场电位反应。在肌张力障碍受试者中，我们发现听觉反馈与负偏转上的高伽马振荡的存在相关，其形态类似于人类鼻皮质中描述的尖锐波波纹复合体。这些在帕金森病受试者中不存在。与正确的试验性能相比，不正确的试验性能改变了高伽玛爆发的时间特性。两组在占主导地位的 GPi 中对“不正确”的试验表现表现出强大的低频响应，但在 theta 频率下对非占主导地位的 GPi 没有表现出强烈的低频响应。我们的结果表明，即使施用多巴胺能药物，与纹状体依赖性记忆功能相关的细胞过程也可能在帕金森病中选择性受损，但错误检测机制得以保留。
The motor symptoms of both Parkinson’s disease and focal dystonia arise from dysfunction of the basal ganglia, and are improved by pallidotomy or deep brain stimulation of the Globus Pallidus interna (GPi). However, Parkinson’s disease is associated with a greater degree of basal ganglia-dependent learning impairment than dystonia. We attempt to understand this observation in terms of a comparison of the electrophysiology of the output of the basal ganglia between the two conditions. We use the natural experiment offered by Deep Brain Stimulation to compare GPi local field potential responses in subjects with Parkinson’s disease compared to subjects with dystonia performing a forced-choice decision-making task with sensory feedback. In dystonic subjects, we found that auditory feedback was associated with the presence of high gamma oscillations nestled on a negative deflection, morphologically similar to sharp wave ripple complexes described in human rhinal cortex. These were not present in Parkinson’s disease subjects. The temporal properties of the high gamma burst were modified by incorrect trial performance compared to correct trial performance. Both groups exhibited a robust low frequency response to ‘incorrect’ trial performance in dominant GPi but not non-dominant GPi at theta frequency. Our results suggest that cellular processes associated with striatum-dependent memory function may be selectively impaired in Parkinson’s disease even if dopaminergic drugs are administered, but that error detection mechanisms are preserved.