Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study
Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study
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DOI：
10.1136/jech-2022-219142
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发表时间：
2022-06-22
影响因子：
6.3
通讯作者：
Tang, Yuhan
中科院分区：
文献类型：
--
作者：
Chen, Li;Yin, Xingzhu;Tang, Yuhan
背景糖尿病的病因复杂，治疗策略有限。越来越多的动物研究表明，有针对性的抗衰老可以改善糖尿病的结果。然而，人口证据有限。本研究旨在评估生物老化与糖尿病患者全因死亡率和特定原因死亡率之间的关系。方法选取1999-2014年全国健康与营养调查中的5278例糖尿病患者为研究对象。从不同的角度来衡量生物老化，包括表型年龄，生物年龄，端粒长度和klotho浓度。表型/生物学年龄加速是表型/生物学年龄对实足年龄进行回归时线性模型产生的残差。考克斯比例风险模型被用来研究老龄化和全因，心血管疾病（CVD）和癌症死亡率之间的关系。结果在中位随访7.3年的时间里，1355例糖尿病患者死亡。死亡率与表型年龄加速呈正线性相关（HR全因1.04; HRCVD 1.04; HR癌症1.04，p
Background The aetiology of diabetes is complex with limited treatment strategies. Growing animal studies have shown that targeted antiageing can improve the outcomes of diabetes. However, population evidence is limited. This study aims to evaluate the associations of biological ageing with all-cause and cause-specific mortality among people with diabetes. Methods A total of 5278 people with diabetes from the National Health and Nutrition Examination Survey 1999-2014 were included. Biological ageing was measured from different perspectives, including phenotypic age, biological age, telomere length and klotho concentration. Phenotypic/biological age acceleration was the residual resulting from a linear model when regressing phenotypic/biological age on chronological age. Cox proportional hazards models were used to examine the relationships between ageing and all-cause, cardiovascular disease (CVD), and cancer mortality. Results Over median follow-up for 7.3 years, 1355 diabetics died. There was a positive and linear association of mortality with phenotypic age acceleration (HRall-cause 1.04; HRCVD 1.04; HRcancer 1.04, p