Osteoclast formation and differentiation: an overview.
Osteoclast formation and differentiation: an overview.
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DOI：
10.11480/jmds.590301
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发表时间：
2012-11
影响因子：
--
通讯作者：
N. Soysa;N. Alles;K. Aoki;K. Ohya
中科院分区：
文献类型：
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作者：
N. Soysa;N. Alles;K. Aoki;K. Ohya
破骨细胞是造血来源的多核细胞，具有独特的骨吸收能力。破骨细胞是由骨髓祖细胞通过单核前体细胞融合的过程产生的。RANK-RANKL信号转导作为调节破骨细胞分化的主要信号的鉴定是骨生物学领域的重大突破。此外，在破骨细胞形成和分化的分子机制方面也有了显著的发现。尽管破骨细胞在骨建模和重塑中至关重要，但骨相关疾病如骨质疏松症、佩吉特病和类风湿性关节炎（其中发生加速的骨吸收）对社会造成了重大的社会经济负担。因此，更好地了解导致破骨细胞分化的途径对于成功管理此类疾病至关重要。这是一个尝试，以一种简洁明了的方式给出了破骨细胞形成和分化的鸟瞰图。
Osteoclasts are multinucleated cells of hematopoietic origin which are unique in their ability to resorb bone. Osteoclasts are generated from myeloid progenitors through a progression that involves the fusion of mononuclear precursor cells. The identification of RANK-RANKL signaling as the main signal regulating osteoclast differentiation was a major breakthrough in the bone biology field. In addition remarkable discoveries have been made to broaden the knowledge of the molecular mechanisms of osteoclast formation and differentiation. Despite the vital requirement of osteoclasts in bone modeling and remodeling, bone-related conditions like osteoporosis, Paget's disease and rheumatoid arthritis where accelerated bone resorption takes place pose a major socioeconomic burden to the society. Hence, a better understanding of the pathways leading to osteoclast differentiation is vital in successfully managing such diseases. This is an attempt to give a birds-eye-view of the players in osteoclast formation and differentiation in a brief and concise manner.