INTIMAL PLUS MEDIAL THICKNESS OF THE ARTERIAL-WALL - A DIRECT MEASUREMENT WITH ULTRASOUND IMAGING
INTIMAL PLUS MEDIAL THICKNESS OF THE ARTERIAL-WALL - A DIRECT MEASUREMENT WITH ULTRASOUND IMAGING
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DOI：
10.1161/01.cir.74.6.1399
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发表时间：
1986-12-01
期刊：
影响因子：
37.8
通讯作者：
PAOLETTI, R
中科院分区：
文献类型：
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作者：
PIGNOLI, P;TREMOLI, E;PAOLETTI, R
对人主动脉和颈总动脉的样本进行体外研究以确定直接测量的可行性（即，而不是来自残余管腔）的动脉壁厚度与B模式实时成像。用同样的方法测量了10名年轻正常男性的颈总动脉。主动脉样本分为A类（相对正常）或B类（有一个或多个动脉粥样硬化斑块）。在所有A级和85%的B级动脉样本中，发现了由两条平行的回声线组成的特征性B模式图像，这两条线之间的距离（内膜+中膜厚度的B模式图像）被测量，并与通过大体和显微镜检查评估的不同组合的被膜厚度相关联。根据这些发现和内膜和外膜的解剖实验结果，我们得出结论，内膜+中膜厚度的B模式成像结果与病理检查测量的内膜+中膜厚度无显著差异。关于B模式成像获得的测量结果与病理结果相比的准确性，我们发现在77%的正常和病理主动脉壁的测量误差小于20%。此外，在体外评价的颈总动脉中B模式确定的内膜+中膜厚度与在年轻受试者中通过该方法在体内确定的内膜+中膜厚度之间没有发现显著差异，表明B模式成像代表了用于测量人体动脉在体内膜+中膜厚度的有用方法。
A study in vitro of specimens of human aortic and common carotid arteries was carried out to determine the feasibility of direct measurement (i.e., not from residual lumen) of arterial wall thickness with B mode real-time imaging. Measurements in vivo by the same technique were also obtained from common carotid arteries of 10 young normal male subjects. Aortic samples were classified as class A (relatively normal) or class B (with one or more atherosclerotic plaques). In all class A and 85% of class B arterial samples a characteristic B mode image composed of two parallel echogenic lines separated by a hypoechoic space was found. The distance between the two lines (B mode image of intimal + medial thickness) was measured and correlated with the thickness of different combinations of tunicae evaluated by gross and microscopic examination. On the basis of these findings and the results of dissection experiments on the intima and adventitia we concluded that results of B mode imaging of intimal + medial thickness did not differ significantly from the intimal + medial thickness measured on pathologic examination. With respect to the accuracy of measurements obtained by B mode imaging as compared with pathologic findings, we found an error of less than 20% for measurements in 77% of normal and pathologic aortic walls. In addition, no significant difference was found between B mode-determined intimal + medial thickness in the common carotid arteries evaluated in vitro and that determined by this method in vivo in young subjects, indicating that B mode imaging represents a useful approach for the measurement of intimal + medial thickness of human arteries in vivo.