MATING-TYPE GENE SWITCHING IN SACCHAROMYCES-CEREVISIAE
MATING-TYPE GENE SWITCHING IN SACCHAROMYCES-CEREVISIAE
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DOI：
10.1016/0168-9525(92)90178-7
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发表时间：
1992-12-01
影响因子：
11.4
通讯作者：
HABER, JE
中科院分区：
文献类型：
--
作者：
HABER, JE
酵母交配型（MAT）基因开关的研究为基因表达调控的多个方面提供了新的视角。MAT转换是通过高度程序化的位点特异性同源重组事件完成的，其中MAT处的交配型特异性序列被从两个未表达供体之一复制的替代DNA序列取代。交配型系统也为研究染色质结构改变对基因沉默的遗传调控，以及遗传信息接受者和几个可能供体之一之间优先重组的基础提供了机会。
The study of yeast mating-type (MAT) gene switching bas provided insights into several aspects of the regulation of gene expression. MAT switching is accomplished by a highly programmed site-specific homologous recombination event ix which mating-type-specific sequences at MAT are replaced by alternative DNA sequences copied from one of two unexpressed donors. The mating-type system bas also provided ax opportunity to study both the genetic regulation of gene silencing by alterations in chromatin structure, and the basis of preferential recombination between a recipient of genetic information and one of several possible donors.