The effect of toothbrushing regimens on the plaque inhibitory properties of an experimental cetylpyridinium chloride mouthrinse
The effect of toothbrushing regimens on the plaque inhibitory properties of an experimental cetylpyridinium chloride mouthrinse
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DOI：
10.1111/j.1600-051x.2006.00974.x
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发表时间：
2006-10-01
影响因子：
6.7
通讯作者：
Hamilton, Amy
中科院分区：
文献类型：
--
作者：
Witt, Jon;Bsoul, Samer;Hamilton, Amy
目的：本研究的目的是确定使用标准含氟牙膏的不同刷牙方案对不含酒精、高生物利用度的 0.07% 氯化十六烷基吡啶 (CPC) 漱口水的牙菌斑抑制特性的影响。 材料和方法：该研究是一项随机、单中心、检查者盲法、四阶段交叉研究，涉及 29 名健康受试者。评估了四种治疗方案：（1）用牙膏刷牙，然后用水冲洗（B-W，阴性对照）； (2) 用洁牙剂刷牙，然后使用 CPC 漱口水 (B-CPC)； (3) 用牙膏刷牙，然后用水漱口，然后使用 CPC 漱口水 (B-W-CPC)； (4)用牙膏刷牙并等待60分钟。使用 CPC 漱口水之前（B-60 分钟-CPC）。在治疗期基线检查前三天，受试者被指示每天两次仅刷牙的舌面，每次最多 60 秒。在基线时，受试者接受了使用奎格利-海因指数 (MQH) 的 Tursky 修正法进行的牙菌斑检查，然后对其牙齿的舌面和颊面进行抛光。在治疗期间，受试者被要求仅用标准氟化物牙膏刷牙的舌面。每天两次用 20ml 实验 CPC 溶液冲洗 30 秒。治疗期最后一天（第 4 天）的前一天晚上，要求受试者在刷牙后不要进行任何口腔卫生、进食和饮水。第 4 天，使用 MQH 指数对牙菌斑进行评分。四个治疗期之间允许有 10 天的正常口腔卫生清洗期。使用交叉设计的协方差分析来分析数据。结果：在任何给定访问中，25 至 29 名受试者可进行评估。对于未刷过的颊面和刷过的舌面，所有三种 CPC 方案均具有高度显着性 (p
Objective: The objective of this study was to determine the effect of various toothbrushing regimens with a standard fluoride dentifrice on the plaque inhibitory properties of an alcohol-free, high bioavailable 0.07% cetylpyridinium chloride (CPC) mouthrinse.Materials and Methods: The study was a randomized, single-centre, examiner blind, four-period cross-over study involving 29 healthy subjects. Four treatment regimens were evaluated: (1) Toothbrushing with dentifrice followed by a water rinse (B-W, negative control); (2) Toothbrushing with dentifrice followed by a CPC mouthrinse use (B-CPC); (3) Toothbrushing with dentifrice followed by a water rinse and then a CPC mouthrinse use (B-W-CPC); and (4) Toothbrushing with dentifrice and waiting 60 min. prior to a CPC mouthrinse use (B-60 min.-CPC). Three days before the baseline exam of treatment periods, subjects were instructed to brush only the lingual surfaces of their teeth for up to 60 s twice daily. At baseline, subjects received a plaque exam using the Turesky modification of the Quigley-Hein index (MQH) followed by a polishing on the lingual and buccal surfaces of their teeth. During treatment periods, subjects were asked to brush only the lingual surfaces of their teeth with a standard fluoride dentifrice. Rinsing with 20ml of the experimental CPC solution was done for 30 s twice daily. The evening before the last day of treatment periods (Day 4), subjects were asked to refrain from any oral hygiene, eating, and drinking after brushing. On Day 4, plaque was scored using the MQH Index. A 10-day wash-out of normal oral hygiene was allowed between each of the four treatment periods. The data were analysed using analysis of covariance for cross-over designs.Results: Twenty-five to 29 subjects were evaluable at any given visit. With respect to unbrushed buccal and brushed lingual surfaces, all three CPC regimens had highly significantly (p