The physiological relevance of the intestinal microbiota - Contributions to human health
The physiological relevance of the intestinal microbiota - Contributions to human health
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DOI：
10.1080/07315724.2007.10719647
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发表时间：
2007-12-01
影响因子：
3.5
通讯作者：
Deutsch, Andrew S.
中科院分区：
文献类型：
--
作者：
Tappenden, Kelly A.;Deutsch, Andrew S.
肠道肠道微生物群是在遗传、环境、饮食和疾病的关键影响下发展的基本微生物的动态混合物。从胃肠道内腔到粘膜，以及个体之间，人群分布沿着不同。总的微生物群数量超过人体中的细胞，占结肠内容物体积的35-50%。肠道微生物群的关键生理功能包括由特定细菌物种直接发挥的保护作用、控制上皮细胞增殖和分化、产生必需的粘膜营养素（例如短链脂肪酸和氨基酸）、防止病原生物过度生长以及刺激肠道免疫。口服益生菌是活微生物，摄入特定数量后，其健康益处超出了固有基本营养的益处。新出现的证据表明益生菌消费在胃肠道健康和疾病中的预防和治疗效用。
The intestinal commensal microbiota is a dynamic mixture of essential microbes that develops under key influences of genetics, environment, diet and disease. Population profiles differ along the gastrointestinal tract, from the lumen to the mucosa, and among individuals. The total microbiota population outnumbers the cells in the human body and accounts for 35-50% of the volume of the colonic content. Key physiological functions of the commensal microbiota include protective effects exerted directly by specific bacterial species, control of epithelial cell proliferation and differentiation, production of essential mucosal nutrients, such as short-chain fatty acids and amino acids, prevention of overgrowth of pathogenic organisms, and stimulation of intestinal immunity. Oral probiotics are living microorganisms that upon ingestion in specific numbers exert health benefits beyond those of inherent basic nutrition. Emerging evidence indicates prophylactic and therapeutic utility for probiotic consumption in gastrointestinal health and disease.