FIBROSING CHOLESTATIC HEPATITIS AND HBV AFTER BONE-MARROW TRANSPLANTATION
FIBROSING CHOLESTATIC HEPATITIS AND HBV AFTER BONE-MARROW TRANSPLANTATION
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DOI：
10.1016/0753-3322(96)82604-7
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发表时间：
1995-01-01
影响因子：
7.5
通讯作者：
MCIVOR, CA
中科院分区：
文献类型：
--
作者：
COOKSLEY, WGE;MCIVOR, CA
由于乙肝病毒的重新激活而导致的肝功能衰竭是骨髓移植的一种罕见的并发症。纤维性淤胆性肝炎是一种最近被描述的肝脏病变，它发生在一些因慢性乙肝病毒感染而接受肝移植的患者中。病变的特点是门静脉周围纤维化，肝细胞气球样变性，明显的胆汁淤积和少许炎症。最近的数据表明，这是一种病毒抗原过度表达的前核心变异形式的细胞病变效应。尽管到目前为止只有一个病例被描述为与骨髓移植(BMT)有关，但在慢性乙肝感染者中越来越多地使用BMT很可能会导致更多的患者得到承认。
Liver failure caused by reactivation of hepatitis B virus (HBV) is an uncommon complication of bone marrow transplantation. Fibrosing cholestatic hepatitis is a recently described liver lesion that develops in some patients undergoing liver transplantation for chronic HBV infection. The lesion is characterised by peri portal fibrosis, ballooning degeneration of hepatocytes, prominent cholestasis and paucity of inflammation. Recent data suggests it is a cytopathic effect of the pre-core mutant form of HBV with over-expression of viral antigens. Although only one case has so far been described associated with bone marrow transplantation (BMT) it is likely that increasing use of BMT in people with chronic HBV infection will lead to further patients being recognised.