Genetics of Rheumatoid Arthritis: An Impressionist Perspective
Genetics of Rheumatoid Arthritis: An Impressionist Perspective
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DOI：
10.1016/j.rdc.2012.05.001
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发表时间：
2012-05-01
影响因子：
2.3
通讯作者：
Jacob, Chaim O.
中科院分区：
文献类型：
--
作者：
Jacob, Noam;Jacob, Chaim O.
类风湿性关节炎（RA）是最常见的风湿性疾病。通过鉴定30多个易感性遗传变异，支持了RA的遗传基础。这些基因中的每一个单独对疾病风险的贡献都很小。此外，与不同类风湿性关节炎亚群和患者种族相关的遗传变异存在显著差异，这强调了该疾病发病机制的复杂性，以及大规模遗传研究的复杂性。这篇综述批判性地评估了最近关于RA遗传贡献的文献，并评估了用于识别这些风险等位基因的方法。
Rheumatoid arthritis (RA) is the most common rheumatic disease. The genetic basis of RA is supported through the identification of more than 30 susceptibility genetic variants. Each of these genes individually makes only a slight contribution to the risk of disease. Moreover, there is significant disparity in the genetic variants associated with different RA subgroups and patient ethnicities, which emphasizes the intricate nature of the disease's pathogenesis, and the complexities involved in large-scale genetic studies. This review evaluates critically the recent literature on the genetic contribution to RA and assesses the methodology used to identify these risk alleles.